Molecular basis of arrhythmias

Manish Shah, Fadi G. Akar, Gordon F. Tomaselli

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations


The characterization of single gene disorders has provided important insights into the molecular pathogenesis of cardiac arrhythmias. Primary electricalal diseases including long-QT syndrome, short-QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia have been associated with mutations in a variety of ion channel subunit genes that promote arrhythmogenesis. Pathological remodeling of ionic currents and network properties of the heart critical for normal electrical propagation plays a critical role in the initiation and maintenance of acquired arrhythmias. This review focuses on the molecular and cellular basis of electrical activity in the heart under normal and pathophysiological conditions to provide insights into the fundamental mechanisms of inherited and acquired cardiac arrhythmias. Improved understanding of the basic biology of cardiac arrhythmias holds the promise of identifying new molecular targets for the treatment of cardiac arrhythmias.

Original languageEnglish (US)
Pages (from-to)2517-2529
Number of pages13
Issue number16
StatePublished - Oct 18 2005


  • Arrhythmia
  • Electrophysiology
  • Genetics
  • Ion channels
  • Molecular biology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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