@article{5cedb7013f92429d9125e782307e4261,
title = "Molecular and cellular reorganization of neural circuits in the human lineage",
abstract = "To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type–specific species expression differences in genes representing distinct functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocortex. Our integrated analysis of the generated data revealed diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.",
author = "Sousa, {Andr{\'e} M.M.} and Ying Zhu and Raghanti, {Mary Ann} and Kitchen, {Robert R.} and Marco Onorati and Tebbenkamp, {Andrew T.N.} and Bernardo Stutz and Meyer, {Kyle A.} and Mingfeng Li and Kawasawa, {Yuka Imamura} and Fuchen Liu and Perez, {Raquel Garcia} and Marta Mele and Tiago Carvalho and Mario Skarica and Gulden, {Forrest O.} and Mihovil Pletikos and Akemi Shibata and Stephenson, {Alexa R.} and Edler, {Melissa K.} and Ely, {John J.} and Elsworth, {John D.} and Horvath, {Tamas L.} and Hof, {Patrick R.} and Hyde, {Thomas M.} and Kleinman, {Joel E.} and Weinberger, {Daniel R.} and Mark Reimers and Lifton, {Richard P.} and Mane, {Shrikant M.} and Noonan, {James P.} and State, {Matthew W.} and Lein, {Ed S.} and Knowles, {James A.} and Tomas Marques-Bonet and Sherwood, {Chet C.} and Gerstein, {Mark B.} and Nenad Sestan",
note = "Funding Information: Data are available at National Center for Biotechnology Information BioProjects (accession number PRJNA236446). We thank A. Bauernfeind, M. Horn, D. Singh, G. Terwilliger, I. B. Toxopeus, B. Wicinski, and S. Wilson for assistance with tissue acquisition and processing, and the Alamogordo Primate Facility and the Primate Brain Bank, Netherlands Institute for Neuroscience, for providing primate tissue. Data was generated as part of the PsychENCODE Consortium, supported by MH103339, MH106934, and MH110926. Additional support was provided by NIH grants MH109904, MH106874, AG048918, DK111178, and NS092988 (National Chimpanzee Brain Resource), the Kavli Foundation, the James S. McDonnell Foundation, NSF grant BCS-1316829, MINECO BFU2014-55090-P (FEDER), Howard Hughes International Early Career, and Secretaria d{\textquoteright}Universitats i Recerca del Departament d{\textquoteright}Economia i Coneixement de la Generalitat de Catalunya. The supplementary materials contain additional data. Publisher Copyright: {\textcopyright} 2017, American Association for the Advancement of Science. All rights reserved.",
year = "2017",
month = nov,
day = "24",
doi = "10.1126/science.aan3456",
language = "English (US)",
volume = "358",
pages = "1027--1032",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6366",
}