Abstract
The development and analysis of biophysical detailed computational models of physiolical systems is beginning to provide an important tool for relating changes in gene expression to changes in biological function at the levels of cell and tissue in both health and disease. We will first illustrate this approach by using a recently developed 'common pool' model of the canine ventricular myocyte. We will present experimental evidence supporting this fundamental role of calcium in regulation of AP characteristics. Finally, given the importance o calcium in regulation of the AP, we will extend these studies to a new class of ventricular cell model combining the stochastic simulation of mechanisms of local control of Ca release with numerical integration of the system of deterministic equations describing the full complement of membrane currents and transporters within the cell.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S-30 |
| Journal | Annals of biomedical engineering |
| Volume | 28 |
| Issue number | SUPPL. 1 |
| State | Published - 2000 |
| Event | 2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: Oct 12 2000 → Oct 14 2000 |
ASJC Scopus subject areas
- Biomedical Engineering