TY - JOUR
T1 - Modulation of J774.1 Macrophage L-arginine metabolism by intracellular Mycobacterium bovis BCG
AU - Peteroy-Kelly, Marcy A.
AU - Venketaraman, Vishwanath
AU - Talaue, Meliza
AU - Seth, Anjali
AU - Connell, Nancy D.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Using a Mycobacterium bovis BCG mutant (AS1) lacking a Bacillus subtilis L-arginine transporter homolog, we demonstrate here that the interaction between intracellular mycobacteria and the macrophage with respect to L-arginine transport and metabolism is quite complex. Intracellular AS1 stimulates macrophage L-arginine transport and accumulates 2.5-fold more 3H label derived from L-arginine than does the wild type. These studies suggest that the accumulation of 3H label reflects the acquisition of metabolites of L-arginine produced by the macrophage.
AB - Using a Mycobacterium bovis BCG mutant (AS1) lacking a Bacillus subtilis L-arginine transporter homolog, we demonstrate here that the interaction between intracellular mycobacteria and the macrophage with respect to L-arginine transport and metabolism is quite complex. Intracellular AS1 stimulates macrophage L-arginine transport and accumulates 2.5-fold more 3H label derived from L-arginine than does the wild type. These studies suggest that the accumulation of 3H label reflects the acquisition of metabolites of L-arginine produced by the macrophage.
UR - http://www.scopus.com/inward/record.url?scp=0037306512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037306512&partnerID=8YFLogxK
U2 - 10.1128/IAI.71.2.1011-1015.2003
DO - 10.1128/IAI.71.2.1011-1015.2003
M3 - Article
C2 - 12540586
AN - SCOPUS:0037306512
SN - 0019-9567
VL - 71
SP - 1011
EP - 1015
JO - Infection and immunity
JF - Infection and immunity
IS - 2
ER -