TY - JOUR
T1 - Modulation of host immunity by tick saliva
AU - Kotál, Jan
AU - Langhansová, Helena
AU - Lieskovská, Jaroslava
AU - Andersen, John F.
AU - Francischetti, Ivo M.B.
AU - Chavakis, Triantafyllos
AU - Kopecký, Jan
AU - Pedra, Joao H.F.
AU - Kotsyfakis, Michail
AU - Chmelař, Jindřich
N1 - Funding Information:
We thank Nextgenediting ( www.nextgenediting.com ) for providing editorial assistance and the anonymous reviewers for their constructive comments. This work was supported by the Grant Agency of the Czech Republic (GACR grant P502/12/2409 to MK), the Academy of Sciences of the Czech Republic (grant no. RVO60077344 to the Biology Center—Institute of Parasitology), and the 7th Framework Program of the European Union (EU FP7; Marie Curie Reintegration grant PIRG07-GA-2010-268177 to MK). This publication reflects only the authors' views and the European Union is not liable for any use that may be made of the information contained herein. MK and JHFP were supported by the National Institutes of Health ( R01 AI093653 ) and JHFP was supported by start-up funds provided by the University of Maryland, Baltimore School of Medicine . JFA and IMBF were supported by the Intramural Research Program of the Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH; USA). MK received support from the Academy of Sciences of the Czech Republic (Jan Evangelista Purkyne Fellowship).
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015
Y1 - 2015
N2 - Next generation sequencing and proteomics have helped to comprehensively characterize gene expression in tick salivary glands at both the transcriptome and the proteome level. Functional data are, however, lacking. Given that tick salivary secretions are critical to the success of the tick transmission lifecycle and, as a consequence, for host colonization by the pathogens they spread, we thoroughly review here the literature on the known interactions between tick saliva (or tick salivary gland extracts) and the innate and adaptive vertebrate immune system. The information is intended to serve as a reference for functional characterization of the numerous genes and proteins expressed in tick salivary glands with an ultimate goal to develop novel vector and pathogen control strategies. Significance: We overview all the known interactions of tick saliva with the vertebrate immune system. The provided information is important, given the recent developments in high-throughput transcriptomic and proteomic analysis of gene expression in tick salivary glands, since it may serve as a guideline for the functional characterization of the numerous newly-discovered genes expressed in tick salivary glands.
AB - Next generation sequencing and proteomics have helped to comprehensively characterize gene expression in tick salivary glands at both the transcriptome and the proteome level. Functional data are, however, lacking. Given that tick salivary secretions are critical to the success of the tick transmission lifecycle and, as a consequence, for host colonization by the pathogens they spread, we thoroughly review here the literature on the known interactions between tick saliva (or tick salivary gland extracts) and the innate and adaptive vertebrate immune system. The information is intended to serve as a reference for functional characterization of the numerous genes and proteins expressed in tick salivary glands with an ultimate goal to develop novel vector and pathogen control strategies. Significance: We overview all the known interactions of tick saliva with the vertebrate immune system. The provided information is important, given the recent developments in high-throughput transcriptomic and proteomic analysis of gene expression in tick salivary glands, since it may serve as a guideline for the functional characterization of the numerous newly-discovered genes expressed in tick salivary glands.
KW - Adaptive immunity
KW - Innate immunity
KW - Saliva
KW - Salivary glands
KW - Tick
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U2 - 10.1016/j.jprot.2015.07.005
DO - 10.1016/j.jprot.2015.07.005
M3 - Review article
C2 - 26189360
AN - SCOPUS:84938308298
SN - 1874-3919
VL - 128
SP - 58
EP - 68
JO - Journal of Proteomics
JF - Journal of Proteomics
ER -