Modulating T-cell homeostasis with IL-7: Preclinical and clinical studies

C. M. Capitini; A. A. Chisti; C. L. MacKall

doi:10.1111/j.1365-2796.2009.02085.x

Modulating T-cell homeostasis with IL-7: Preclinical and clinical studies

C. M. Capitini, A. A. Chisti, C. L. MacKall

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Abstract

Capitini CM, Chisti AA, Mackall CL (National Cancer Institute, National Institutes of Health, Bethesda, MD; USA). Modulating T-cell homeostasis with IL-7: preclinical and clinical studies (Review).J Intern Med 2009; 266: 141-153. Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.

Original language	English (US)
Pages (from-to)	141-153
Number of pages	13
Journal	Journal of Internal Medicine
Volume	266
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2796.2009.02085.x
State	Published - Aug 2009
Externally published	Yes

Keywords

Cytokines
Immunotherapy
Lymphopenia
T cell

ASJC Scopus subject areas

Internal Medicine

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10.1111/j.1365-2796.2009.02085.x

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title = "Modulating T-cell homeostasis with IL-7: Preclinical and clinical studies",

abstract = "Capitini CM, Chisti AA, Mackall CL (National Cancer Institute, National Institutes of Health, Bethesda, MD; USA). Modulating T-cell homeostasis with IL-7: preclinical and clinical studies (Review).J Intern Med 2009; 266: 141-153. Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.",

keywords = "Cytokines, Immunotherapy, Lymphopenia, T cell",

author = "Capitini, {C. M.} and Chisti, {A. A.} and MacKall, {C. L.}",

year = "2009",

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AB - Capitini CM, Chisti AA, Mackall CL (National Cancer Institute, National Institutes of Health, Bethesda, MD; USA). Modulating T-cell homeostasis with IL-7: preclinical and clinical studies (Review).J Intern Med 2009; 266: 141-153. Interleukin-7 (IL-7) is required for the development and survival of T cells and plays a critical role in modulating T-cell homeostasis. This review will address current understanding of IL-7 biology, review recent clinical experiences and discuss potential future clinical applications of IL-7, or IL-7 blockade, in the setting of disease.

KW - Cytokines

KW - Immunotherapy

KW - Lymphopenia

KW - T cell

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Modulating T-cell homeostasis with IL-7: Preclinical and clinical studies

Abstract

Keywords

ASJC Scopus subject areas

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