Modifying matrix remodeling to prevent heart failure

K. Y. Deleon; A. Yabluchanskiy; M. D. Winniford; R. A. Lange; R. J. Chilton; M. L. Lindsey

doi:10.1533/9780857096708.1.41

Modifying matrix remodeling to prevent heart failure

K. Y. Deleon, A. Yabluchanskiy, M. D. Winniford, R. A. Lange, R. J. Chilton, M. L. Lindsey

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.

Original language	English (US)
Title of host publication	Cardiac Regeneration and Repair
Publisher	Elsevier Ltd.
Pages	41-60
Number of pages	20
Volume	1
ISBN (Print)	9780857096586
DOIs	https://doi.org/10.1533/9780857096708.1.41
State	Published - Feb 2014
Externally published	Yes

Keywords

Cardiac remodeling
Extracellular matrix
Heart failure
Matrix metalloproteinases
Myocardial infarction

ASJC Scopus subject areas

Medicine(all)
Dentistry(all)

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10.1533/9780857096708.1.41

Cite this

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AU - Deleon, K. Y.

AU - Yabluchanskiy, A.

AU - Winniford, M. D.

AU - Lange, R. A.

AU - Chilton, R. J.

AU - Lindsey, M. L.

PY - 2014/2

Y1 - 2014/2

N2 - In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.

AB - In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.

KW - Cardiac remodeling

KW - Extracellular matrix

KW - Heart failure

KW - Matrix metalloproteinases

KW - Myocardial infarction

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PB - Elsevier Ltd.

ER -

Modifying matrix remodeling to prevent heart failure

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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