Abstract
In the USA, cardiovascular disease is the leading cause of morbidity and mortality, accounting for approximately 40% of all deaths. Myocardial infarction or its sequelae is the primary cause of cardiovascular disease death. Despite advances in novel therapeutic strategies over the past 30 years, heart failure morbidity and mortality remain high for the post-myocardial infarction patient. Extracellular matrix remodeling and its role in heart failure are explored in this chapter: the key players involved, current therapeutic options and future trends are discussed.
Original language | English (US) |
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Title of host publication | Cardiac Regeneration and Repair |
Publisher | Elsevier Ltd. |
Pages | 41-60 |
Number of pages | 20 |
Volume | 1 |
ISBN (Print) | 9780857096586 |
DOIs | |
State | Published - Feb 2014 |
Externally published | Yes |
Keywords
- Cardiac remodeling
- Extracellular matrix
- Heart failure
- Matrix metalloproteinases
- Myocardial infarction
ASJC Scopus subject areas
- Medicine(all)
- Dentistry(all)