TY - JOUR
T1 - Modification of rat operant behavior by ozone exposure
AU - Weiss, Bernard
AU - Ferin, Juraj
AU - Merigan, William
AU - Stern, Sander
AU - Cox, Christopher
N1 - Funding Information:
1 This work was supported in part by Grant ES-01247 from NIEHS and in part under Contract DE-AC02-76EV03490 with the U.S. Department of Energy at the Department of Radiation Biology and Biophysics, University of Rochester (Report No. UR-3490-1923). * Author to whom reprint requests should be sent: Department of Radiation Biology and Biophysics, University of Rochester Medical Center, Rochester, N.Y. 14642.
PY - 1981/4
Y1 - 1981/4
N2 - Ozone exposure may induce extrapulmonary consequences, such as reductions in the spontaneous activity of rodents, or complaints in humans of lethargy, headache, chest discomfort, and other subjective symptoms. Further evidence of behavioral disruption was provided by this experiment. Twelve rats were trained to perform a bar-pressing response maintained by food reward. Food pellets were delivered according to a fixed interval 5-min reinforcement schedule. Exposures encompassed a range of concentrations from 0.1 to 2.0 ppm. A single exposure lasted 6 hr, and successive exposures were separated by at least 6 days. Compared to performance under control conditions (ambient air), response rates fell linearly from 0.1 to 1.4 ppm. During individual 6-hr exposures, the rates declined from the beginning to the end of the session. These results, given the sedentary nature of the task, reflect reduced inclination rather than impaired physiological capacity to respond.
AB - Ozone exposure may induce extrapulmonary consequences, such as reductions in the spontaneous activity of rodents, or complaints in humans of lethargy, headache, chest discomfort, and other subjective symptoms. Further evidence of behavioral disruption was provided by this experiment. Twelve rats were trained to perform a bar-pressing response maintained by food reward. Food pellets were delivered according to a fixed interval 5-min reinforcement schedule. Exposures encompassed a range of concentrations from 0.1 to 2.0 ppm. A single exposure lasted 6 hr, and successive exposures were separated by at least 6 days. Compared to performance under control conditions (ambient air), response rates fell linearly from 0.1 to 1.4 ppm. During individual 6-hr exposures, the rates declined from the beginning to the end of the session. These results, given the sedentary nature of the task, reflect reduced inclination rather than impaired physiological capacity to respond.
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U2 - 10.1016/0041-008X(81)90429-4
DO - 10.1016/0041-008X(81)90429-4
M3 - Article
C2 - 7245199
AN - SCOPUS:0019395552
SN - 0041-008X
VL - 58
SP - 244
EP - 251
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 2
ER -