Modification of a vibrating-tube density meter for precise temperature scanning

F. H. Anthony, R. L. Biltonen, E. Freire

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We have devised a method of temperature scanning with a vibrating-U-tube density meter in which temperature fluctuations are much reduced compared to those using a constant or programmable thermostat. The standard error of a density measurement is 5 × 10-7 g/ml. Volume changes associated with conformational changes of macromolecular systems can be precisely measured. Using this instrument the volume expansion-melting curves of lipid dispersions have been obtained. The curves are similar in shape and resolution to the excess heat-capacity curves derived from differential scanning calorimetry performed on the same sample. Temperature scanning allows measurements of expansivity as well as apparent volume throughout a temperature range of interest.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalAnalytical biochemistry
Issue number1
StatePublished - Sep 1 1981

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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