Moderate and Severe Traumatic Brain Injury. Pathophysiology and Management.

Anthony R. Frattalone, Geoffrey S.F. Ling

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Traumatic brain injury (TBI) is a serious disorder that is all too common. TBI ranges inseverity from mild concussion to a severe life-threatening state. Across this spectrum, rational therapeutic approaches exist. Early identification that TBI has occurred in a patient is paramount to optimal outcome. Proper clinical management should be instituted as soon as possible by appropriately trained medical providers. More seriously injured patients must be triaged to advanced care centers. It is only through this rational approach to TBI that patients may expect to achieve optimal clinical and functional outcome.

Original languageEnglish (US)
Pages (from-to)309-319
Number of pages11
JournalNeurosurgery clinics of North America
Issue number3
StatePublished - Jul 2013
Externally publishedYes


  • CPP (cerebral perfusion pressure)
  • Clinical practice guidelines
  • Coma
  • Concussion
  • Head injury
  • ICP (intracranial pressure)
  • Traumatic brain injury

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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