Abstract
Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | Unit 9.13 |
| Journal | Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] |
| Volume | Chapter 9 |
| DOIs | |
| State | Published - Nov 2002 |
ASJC Scopus subject areas
- General Neuroscience
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