Models of amyotrophic lateral sclerosis.

Mandy Jackson, Raquelli Ganel, Jeffrey D. Rothstein

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder caused by degeneration of the motor neurons in cortex, brainstem and spinal cord. Two experimental models of ALS are described in this unit: organotypic cultures of spinal cord, and transgenic mice expressing a human mutant superoxide dismutase 1 (SOD1) gene. Appropriate animal and cell culture models of ALS can be used to help unravel the sequence of events in motor neuronal degeneration and test potential therapies.

Original languageEnglish (US)
Pages (from-to)Unit 9.13
JournalCurrent protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]
VolumeChapter 9
StatePublished - Nov 2002

ASJC Scopus subject areas

  • Neuroscience(all)


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