Modelling cutaneous squamous cell carcinoma for laboratory research

Edwin Kumah, Kristin Bibee

Research output: Contribution to journalReview articlepeer-review


Cutaneous squamous cell carcinoma (cSCC) leads to significant morbidity for patients with progression and metastases. However, the molecular underpinnings of these tumors are still poorly understood. Dissecting human cSCC pathogenesis amplifies the exigence for preclinical models that mimic invasion and nodal spread. This review discusses the currently available models, including two- and three-dimensional tissue cultures, syngeneic and transgenic mice, and cell line-derived and patient-derived xenografts. We further highlight studies that have utilized the different models, considering how they recapitulate specific hallmarks of cSCC. Finally, we discuss the advantages, limitations and future research directions.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalExperimental Dermatology
Issue number2
StatePublished - Feb 2023


  • cSCC
  • cutaneous squamous cell carcinoma
  • in vitro models
  • keratinocyte carcinoma
  • mouse models
  • preclinical model systems

ASJC Scopus subject areas

  • Dermatology
  • Molecular Biology
  • Biochemistry

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