Modelling cutaneous squamous cell carcinoma for laboratory research

Edwin Kumah; Kristin Bibee

doi:10.1111/exd.14706

Modelling cutaneous squamous cell carcinoma for laboratory research

Edwin Kumah, Kristin Bibee

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Cutaneous squamous cell carcinoma (cSCC) leads to significant morbidity for patients with progression and metastases. However, the molecular underpinnings of these tumors are still poorly understood. Dissecting human cSCC pathogenesis amplifies the exigence for preclinical models that mimic invasion and nodal spread. This review discusses the currently available models, including two- and three-dimensional tissue cultures, syngeneic and transgenic mice, and cell line-derived and patient-derived xenografts. We further highlight studies that have utilized the different models, considering how they recapitulate specific hallmarks of cSCC. Finally, we discuss the advantages, limitations and future research directions.

Original language	English (US)
Pages (from-to)	117-125
Number of pages	9
Journal	Experimental Dermatology
Volume	32
Issue number	2
DOIs	https://doi.org/10.1111/exd.14706
State	Published - Feb 2023

Keywords

cSCC
cutaneous squamous cell carcinoma
in vitro models
keratinocyte carcinoma
mouse models
preclinical model systems

ASJC Scopus subject areas

Dermatology
Molecular Biology
Biochemistry

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10.1111/exd.14706

Cite this

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title = "Modelling cutaneous squamous cell carcinoma for laboratory research",

abstract = "Cutaneous squamous cell carcinoma (cSCC) leads to significant morbidity for patients with progression and metastases. However, the molecular underpinnings of these tumors are still poorly understood. Dissecting human cSCC pathogenesis amplifies the exigence for preclinical models that mimic invasion and nodal spread. This review discusses the currently available models, including two- and three-dimensional tissue cultures, syngeneic and transgenic mice, and cell line-derived and patient-derived xenografts. We further highlight studies that have utilized the different models, considering how they recapitulate specific hallmarks of cSCC. Finally, we discuss the advantages, limitations and future research directions.",

keywords = "cSCC, cutaneous squamous cell carcinoma, in vitro models, keratinocyte carcinoma, mouse models, preclinical model systems",

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AU - Bibee, Kristin

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PY - 2023/2

Y1 - 2023/2

N2 - Cutaneous squamous cell carcinoma (cSCC) leads to significant morbidity for patients with progression and metastases. However, the molecular underpinnings of these tumors are still poorly understood. Dissecting human cSCC pathogenesis amplifies the exigence for preclinical models that mimic invasion and nodal spread. This review discusses the currently available models, including two- and three-dimensional tissue cultures, syngeneic and transgenic mice, and cell line-derived and patient-derived xenografts. We further highlight studies that have utilized the different models, considering how they recapitulate specific hallmarks of cSCC. Finally, we discuss the advantages, limitations and future research directions.

AB - Cutaneous squamous cell carcinoma (cSCC) leads to significant morbidity for patients with progression and metastases. However, the molecular underpinnings of these tumors are still poorly understood. Dissecting human cSCC pathogenesis amplifies the exigence for preclinical models that mimic invasion and nodal spread. This review discusses the currently available models, including two- and three-dimensional tissue cultures, syngeneic and transgenic mice, and cell line-derived and patient-derived xenografts. We further highlight studies that have utilized the different models, considering how they recapitulate specific hallmarks of cSCC. Finally, we discuss the advantages, limitations and future research directions.

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Modelling cutaneous squamous cell carcinoma for laboratory research

Abstract

Keywords

ASJC Scopus subject areas

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