Modeling the economic value of a Chagas' disease therapeutic vaccine

Bruce Y. Lee, Kristina M. Bacon, Angela R. Wateska, Maria Elena Bottazzi, Eric Dumonteil, Peter J. Hotez

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


The health burden of Chagas' disease (resulting from Trypanosoma cruzi infection) in Latin America (estimated to outweigh that of malaria by 5-fold and affect 2-6 million people in Mexico alone) has motivated development of therapeutic vaccines to prevent infection progression to severe disease. Our economic model for a Chagas' therapeutic vaccine in Mexico suggests that a vaccine would be highly cost-effective and in many cases economically dominant (providing both cost savings and health benefits) throughout a range of protection durations, severe adverse event risk and dosing regimens and would be most likely to provide a positive return on investment if the vaccine prevented (rather than delayed) the onset of cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)1293-1301
Number of pages9
JournalHuman Vaccines and Immunotherapeutics
Issue number9
StatePublished - Sep 2012
Externally publishedYes


  • Chagas' disease
  • Chagas' therapeutic vaccine
  • Cost-effectiveness
  • Mexico
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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