Modeling spatial heterogeneity of disease risk and evaluation of the impact of vaccination

Mohammad Ali; Michael Emch; Mohammad Yunus; John Clemens

doi:10.1016/j.vaccine.2009.03.085

Modeling spatial heterogeneity of disease risk and evaluation of the impact of vaccination

Mohammad Ali, Michael Emch, Mohammad Yunus, John Clemens

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We reanalyzed data from a phase III trial for the killed oral cholera vaccine to test two hypotheses: there will be a greater impact of the vaccine in areas where there is a low force of infection, and the spatial pattern of disease transmission will change after a mass vaccination campaign. Spatial regression was used to test these hypotheses accounting for spatial heterogeneity in disease and vaccine coverage. The results of the analyses confirm both hypotheses. The paper also shows how spatial analysis can be used to understand the impact of vaccination when there are spatially heterogeneous disease distributions.

Original language	English (US)
Pages (from-to)	3724-3729
Number of pages	6
Journal	Vaccine
Volume	27
Issue number	28
DOIs	https://doi.org/10.1016/j.vaccine.2009.03.085
State	Published - Jun 8 2009
Externally published	Yes

Keywords

Cholera
Spatial analysis
Vaccine

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2009.03.085

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AB - We reanalyzed data from a phase III trial for the killed oral cholera vaccine to test two hypotheses: there will be a greater impact of the vaccine in areas where there is a low force of infection, and the spatial pattern of disease transmission will change after a mass vaccination campaign. Spatial regression was used to test these hypotheses accounting for spatial heterogeneity in disease and vaccine coverage. The results of the analyses confirm both hypotheses. The paper also shows how spatial analysis can be used to understand the impact of vaccination when there are spatially heterogeneous disease distributions.

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KW - Spatial analysis

KW - Vaccine

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Modeling spatial heterogeneity of disease risk and evaluation of the impact of vaccination

Abstract

Keywords

ASJC Scopus subject areas

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