Modeling spatial heterogeneity of disease risk and evaluation of the impact of vaccination

Mohammad Ali, Michael Emch, Mohammad Yunus, John Clemens

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We reanalyzed data from a phase III trial for the killed oral cholera vaccine to test two hypotheses: there will be a greater impact of the vaccine in areas where there is a low force of infection, and the spatial pattern of disease transmission will change after a mass vaccination campaign. Spatial regression was used to test these hypotheses accounting for spatial heterogeneity in disease and vaccine coverage. The results of the analyses confirm both hypotheses. The paper also shows how spatial analysis can be used to understand the impact of vaccination when there are spatially heterogeneous disease distributions.

Original languageEnglish (US)
Pages (from-to)3724-3729
Number of pages6
Issue number28
StatePublished - Jun 8 2009
Externally publishedYes


  • Cholera
  • Spatial analysis
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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