Modeling cardiac ion channel conductivity: Model fitting via simulation

John L. Maryak; Richard H. Smith; Raimond L. Winslow

Modeling cardiac ion channel conductivity: Model fitting via simulation

John L. Maryak, Richard H. Smith, Raimond L. Winslow

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

Abstract

We describe a Markov state model for a cloned potassium channel of the human heart (I_KvLQT1). The parameters of the model are determined by a least-squares fit of predicted vs. measured data. The fitting process is achieved by using the `SPSA' optimizer to sequentially choose trial values of the parameters. At each choice of parameter value, a loss function is computed by simulating the action of the channel at that trial parameter value. When the optimizer has converged, the parameter value represents the best fit.

Original language	English (US)
Pages (from-to)	1587-1590
Number of pages	4
Journal	Winter Simulation Conference Proceedings
Volume	2
State	Published - Dec 1 1998
Event	Proceedings of the 1998 Winter Simulation Conference, WSC. Part 1 (of 2) - Washington, DC, USA Duration: Dec 13 1998 → Dec 16 1998

ASJC Scopus subject areas

Software
Modeling and Simulation
Safety, Risk, Reliability and Quality
Chemical Health and Safety
Applied Mathematics

Cite this

@article{7d1c6efc6ef44846a333ac6a9737ef25,

title = "Modeling cardiac ion channel conductivity: Model fitting via simulation",

abstract = "We describe a Markov state model for a cloned potassium channel of the human heart (IKvLQT1). The parameters of the model are determined by a least-squares fit of predicted vs. measured data. The fitting process is achieved by using the `SPSA' optimizer to sequentially choose trial values of the parameters. At each choice of parameter value, a loss function is computed by simulating the action of the channel at that trial parameter value. When the optimizer has converged, the parameter value represents the best fit.",

author = "Maryak, {John L.} and Smith, {Richard H.} and Winslow, {Raimond L.}",

year = "1998",

month = dec,

day = "1",

language = "English (US)",

volume = "2",

pages = "1587--1590",

journal = "Winter Simulation Conference Proceedings",

issn = "0275-0708",

note = "Proceedings of the 1998 Winter Simulation Conference, WSC. Part 1 (of 2) ; Conference date: 13-12-1998 Through 16-12-1998",

}

TY - JOUR

T1 - Modeling cardiac ion channel conductivity

T2 - Proceedings of the 1998 Winter Simulation Conference, WSC. Part 1 (of 2)

AU - Maryak, John L.

AU - Smith, Richard H.

AU - Winslow, Raimond L.

PY - 1998/12/1

Y1 - 1998/12/1

N2 - We describe a Markov state model for a cloned potassium channel of the human heart (IKvLQT1). The parameters of the model are determined by a least-squares fit of predicted vs. measured data. The fitting process is achieved by using the `SPSA' optimizer to sequentially choose trial values of the parameters. At each choice of parameter value, a loss function is computed by simulating the action of the channel at that trial parameter value. When the optimizer has converged, the parameter value represents the best fit.

AB - We describe a Markov state model for a cloned potassium channel of the human heart (IKvLQT1). The parameters of the model are determined by a least-squares fit of predicted vs. measured data. The fitting process is achieved by using the `SPSA' optimizer to sequentially choose trial values of the parameters. At each choice of parameter value, a loss function is computed by simulating the action of the channel at that trial parameter value. When the optimizer has converged, the parameter value represents the best fit.

UR - http://www.scopus.com/inward/record.url?scp=0032275850&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032275850&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0032275850

SN - 0275-0708

VL - 2

SP - 1587

EP - 1590

JO - Winter Simulation Conference Proceedings

JF - Winter Simulation Conference Proceedings

Y2 - 13 December 1998 through 16 December 1998

ER -

Modeling cardiac ion channel conductivity: Model fitting via simulation

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this