@article{30e6c28121ea4ccaae37bc8ca8b93b6f,
title = "Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment",
abstract = "Alveolar soft part sarcoma (ASPS), a deadly soft tissue malignancy with a predilection for adolescents and young adults, associates consistently with t(X;17) translocations that generate the fusion gene ASPSCR1-TFE3. We proved the oncogenic capacity of this fusion gene by driving sarcomagenesis in mice from conditional ASPSCR1-TFE3 expression. The completely penetrant tumors were indistinguishable from human ASPS by histology and gene expression. They formed preferentially in the anatomic environment highest in lactate, the cranial vault, expressed high levels of lactate importers, harbored abundant mitochondria, metabolized lactate as a metabolic substrate, and responded to the administration of exogenous lactate with tumor cell proliferation and angiogenesis. These data demonstrate lactate's role as a driver of alveolar soft part sarcomagenesis.",
author = "Goodwin, {Matthew L.} and Huifeng Jin and Krystal Straessler and Kyllie Smith-Fry and Zhu, {Ju Fen} and Monument, {Michael J.} and Allie Grossmann and Randall, {R. Lor} and Capecchi, {Mario R.} and Jones, {Kevin B.}",
note = "Funding Information: The authors thank L. Bruce Gladden from Auburn University, Maarten W.N. Nijsten from University Medical Center Groningen, The Netherlands, and Don Ayer from the Department of Oncologic Sciences for helpful conversations regarding lactate physiology and metabolism, Marc Ladanyi from Memorial Sloan Kettering Cancer Center for provision of human cell lines, Matt Hockin of the Department of Human Genetics for provision of the TATCre, Sheryl Tripp from ARUP laboratories for help with immunohistochemistry, Shaobo Pei and Sihem Boudina from the metabolic phenotyping core facility for help with SeaHorse experiments, Brian Dalley from the sequencing core facility for help with the RNAseq, and Tim Mosbruger and Brett Milash from the bioinformatics core facility for help with the RNAseq analysis. This work was directly supported by the Alex{\textquoteright}s Lemonade Stand Foundation (K.B.J.) and the Sherman Coleman Resident Research Award (M.L.G.). K.B.J. receives additional career development support from the Damon Runyon Cancer Research Foundation and National Cancer Institute (NIH K08CA138764). This work was also partly supported by P30CA042014 from the National Cancer Institute and the Huntsman Cancer Foundation. Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",
year = "2014",
month = dec,
day = "8",
doi = "10.1016/j.ccell.2014.10.003",
language = "English (US)",
volume = "26",
pages = "851--862",
journal = "Cancer cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "6",
}