Model-free arterial spin labeling quantification approach for perfusion MRI

Esben Thade Petersen, Tchoyoson Lim, Xavier Golay

Research output: Contribution to journalArticlepeer-review

235 Scopus citations


In this work a model-free arterial spin labeling (ASL) quantification approach for measuring cerebral blood flow (CBF) and arterial blood volume (aBV) is proposed. The method is based on the acquisition of a train of multiple images following the labeling scheme. Perfusion is obtained using deconvolution in a manner similar to that of dynamic susceptibility contrast (DSC) MRI. Local arterial input functions (AIFs) can be estimated by subtracting two perfusion-weighted images acquired with and without crusher gradients, respectively. Furthermore, by knowing the duration of the bolus of tagged arterial blood, one can estimate the aBV on a voxel-by-voxel basis. The maximum of the residue function obtained from the deconvolution of the tissue curve by the AIF is a measure of CBF after scaling by the locally estimated aBV. This method provides averaged gray matter (GM) perfusion values of 38 ± 2 ml/min/100 g and aBV of 0.93% ± 0.06%. The average CBF value is 10% smaller than that obtained on the same data set using the standard general kinetic model (42 ± 2 ml/min/100 g). Monte Carlo simulations were performed to compare this new methodology with parametric fitting by the conventional model.

Original languageEnglish (US)
Pages (from-to)219-232
Number of pages14
JournalMagnetic resonance in medicine
Issue number2
StatePublished - Feb 2006
Externally publishedYes


  • 3.0 Tesla
  • Arterial blood volume
  • Arterial spin labeling
  • Cerebral blood flow
  • Deconvolution
  • Regional perfusion imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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