Mobile DNA elements: Controlling transposition with ATP-dependent molecular switches

Anne E. Stellwagen, Nancy L. Craig

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations


Nucleotide-binding proteins are often used as molecular switches to control the assembly or activity of macromolecular machines. Recent work has revealed that such molecular switches also regulate the spread of some mobile DNA elements. Bacteriophage Mu and the bacterial transposon Tn7 each use an ATP-dependent molecular switch to select a new site for insertion and to coordinate the assembly of the transposition machinery at that site. Strong parallels between these ATP-dependent transposition proteins and other well-characterized molecular switches, such as Ras and EF-Tu, have emerged. Copyright (C) 1998 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)486-490
Number of pages5
JournalTrends in biochemical sciences
Issue number12
StatePublished - Dec 1 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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