Mitochondrial ion channels: Gatekeepers of life and death

Brian O'Rourke, Sonia Carmen Cortassa, Miguel Antonio Aon

Research output: Contribution to journalReview articlepeer-review

196 Scopus citations


Continuous generation of ATP by mitochondrial oxidative phosphorylation is essential to maintain function in mechanically active cells such as cardiomyocytes. Emerging evidence indicates that mitochondrial ion channels activated by reactive oxygen species can induce a mitochondrial "critical" state, which can scale to cause electrical and contractile dysfunction of the cardiac cell and, ultimately, the whole heart. Here we focus on how mitochondrial ion channels participate in life-and-death decisions of the cell and discuss the challenges ahead for translating recent findings into novel therapeutic applications.

Original languageEnglish (US)
Pages (from-to)303-315
Number of pages13
Issue number5
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Physiology


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