TY - JOUR
T1 - Mitochondrial ion channels
T2 - Gatekeepers of life and death
AU - O'Rourke, Brian
AU - Cortassa, Sonia Carmen
AU - Aon, Miguel Antonio
PY - 2005/10
Y1 - 2005/10
N2 - Continuous generation of ATP by mitochondrial oxidative phosphorylation is essential to maintain function in mechanically active cells such as cardiomyocytes. Emerging evidence indicates that mitochondrial ion channels activated by reactive oxygen species can induce a mitochondrial "critical" state, which can scale to cause electrical and contractile dysfunction of the cardiac cell and, ultimately, the whole heart. Here we focus on how mitochondrial ion channels participate in life-and-death decisions of the cell and discuss the challenges ahead for translating recent findings into novel therapeutic applications.
AB - Continuous generation of ATP by mitochondrial oxidative phosphorylation is essential to maintain function in mechanically active cells such as cardiomyocytes. Emerging evidence indicates that mitochondrial ion channels activated by reactive oxygen species can induce a mitochondrial "critical" state, which can scale to cause electrical and contractile dysfunction of the cardiac cell and, ultimately, the whole heart. Here we focus on how mitochondrial ion channels participate in life-and-death decisions of the cell and discuss the challenges ahead for translating recent findings into novel therapeutic applications.
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U2 - 10.1152/physiol.00020.2005
DO - 10.1152/physiol.00020.2005
M3 - Review article
C2 - 16174870
AN - SCOPUS:26844554628
SN - 1548-9213
VL - 20
SP - 303
EP - 315
JO - Physiology
JF - Physiology
IS - 5
ER -