Mitochondrial factors with dual roles in death and survival

W. C. Cheng, S. B. Berman, I. Ivanovska, E. A. Jonas, S. J. Lee, Y. Chen, L. K. Kaczmarek, Fernando J Pineda, J. M. Hardwick

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations


At least in mammals, we have some understanding of how caspases facilitate mitochondria-mediated cell death, but the biochemical mechanisms by which other factors promote or inhibit programmed cell death are not understood. Moreover, most of these factors are only studied after treating cells with a death stimulus. A growing body of new evidence suggests that cell death regulators also have 'day jobs' in healthy cells. Even caspases, mitochondrial fission proteins and pro-death Bcl-2 family proteins appear to have normal cellular functions that promote cell survival. Here, we review some of the supporting evidence and stretch beyond the evidence to seek an understanding of the remaining questions.

Original languageEnglish (US)
Pages (from-to)4697-4705
Number of pages9
Issue number34
StatePublished - Aug 7 2006


  • Aging
  • Apoptosis
  • CED-9
  • Fis1
  • Virus
  • Yeast

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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