Mitochondrial estrogen receptors - new insights into specific functions

James D. Yager, Jin Q. Chen

Research output: Contribution to journalShort surveypeer-review

77 Scopus citations


Estrogen receptor (ER) α and ERβ are present in mitochondria but little is known about their contribution to the overall constellation of cellular responses to 17β-estradiol, which inhibits the early stages of apoptosis through membrane and mitochondrial, but not nuclear, ER signaling pathways. Whereas membrane ER signaling leading to inhibition of apoptosis involves the activation of protein kinase pathways, mitochondrial ER-mediated inhibition involves the direct and/or indirect activation of manganese superoxide dismutase by the mitochondrial ER.

Original languageEnglish (US)
Pages (from-to)89-91
Number of pages3
JournalTrends in Endocrinology and Metabolism
Issue number3
StatePublished - Apr 2007

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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