Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

Huafeng Zhang, Marta Bosch-Marce, Larissa A. Shimoda, Sun Tan Yee, Hyen Baek Jin, Jacob B. Wesley, Frank J. Gonzalez, Gregg L. Semenza

Research output: Contribution to journalArticlepeer-review

1088 Scopus citations


Autophagy is a process by which cytoplasmic organelles can be catabolized either to remove defective structures or as a means of providing macromolecules for energy generation under conditions of nutrient starvation. In this study we demonstrate that mitochondrial autophagy is induced by hypoxia, that this process requires the hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxia, mitochondrial autophagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.

Original languageEnglish (US)
Pages (from-to)10892-10903
Number of pages12
JournalJournal of Biological Chemistry
Issue number16
StatePublished - Apr 18 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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