Mitochondria, oxidants, and aging

Robert S. Balaban; Shino Nemoto; Toren Finkel

doi:10.1016/j.cell.2005.02.001

Mitochondria, oxidants, and aging

Robert S. Balaban
, Shino Nemoto
, Toren Finkel

Research output: Contribution to journal › Article › peer-review

2857 Scopus citations

Abstract

The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.

Original language	English (US)
Pages (from-to)	483-495
Number of pages	13
Journal	Cell
Volume	120
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2005.02.001
State	Published - Feb 25 2005
Externally published	Yes

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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10.1016/j.cell.2005.02.001

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title = "Mitochondria, oxidants, and aging",

abstract = "The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.",

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N2 - The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.

AB - The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span. Numerous cell culture, invertebrate, and mammalian models exist that lend support to this half-century-old hypothesis. Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging.

UR - https://www.scopus.com/pages/publications/13944278132

UR - https://www.scopus.com/pages/publications/13944278132#tab=citedBy

U2 - 10.1016/j.cell.2005.02.001

DO - 10.1016/j.cell.2005.02.001

M3 - Article

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AN - SCOPUS:13944278132

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VL - 120

SP - 483

EP - 495

JO - Cell

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ER -

Mitochondria, oxidants, and aging

Abstract

ASJC Scopus subject areas

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