miRiad Roles for the miR-17-92 Cluster in Development and Disease

Joshua T. Mendell

Research output: Contribution to journalReview articlepeer-review

879 Scopus citations


MicroRNAs (miRNAs) encoded by the miR-17-92 cluster and its paralogs are known to act as oncogenes. Expression of these miRNAs promotes cell proliferation, suppresses apoptosis of cancer cells, and induces tumor angiogenesis. New work reveals essential functions for these miRNAs not only in tumor formation but also during normal development of the heart, lungs, and immune system.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
Issue number2
StatePublished - Apr 18 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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