Abstract
Introduction: As the predominant miRNA regulated by hypoxia, miR-210 correlates with survival in cancer patients. miR-210 may play important roles in regulation of cell growth, angiogenesis and apoptosis in different human tumor models, indicating that it can be used as a therapeutic target. Areas covered: This review covers all literature related to miR-210 in malignant tumors from the past 5 years, and analyzes the biological functions and molecular mechanisms of it. The authors also envisage future developments toward the clinical applications of miR-210 to cancer diagnosis and treatment. Expert opinion: miR-210 may function as a new therapeutic target for anticancer intervention. Considering that the exact function of miR-210 is still not well characterized and understood, more investigations should be performed to promote the success of therapeutic clinical use of miR-210 in cancer.
Original language | English (US) |
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Pages (from-to) | 21-28 |
Number of pages | 8 |
Journal | Expert opinion on therapeutic targets |
Volume | 17 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2013 |
Keywords
- Angiogenesis
- Apoptosis
- Human cancers
- Hypoxia
- MiR-210
- MicroRNA
- Survival
- cell cycle
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Clinical Biochemistry