TY - JOUR
T1 - Minocycline Levels in Tears of Patients With Active Trachoma
AU - Tabbara, Khalid F.
AU - Cooper, Hendrik
PY - 1989
Y1 - 1989
N2 - We determined minocycline levels in human tears and plasma samples using high-performance liquid chromatography. In the first study, we determined the trough tear and plasma levels of minocycline in patients with active trachoma 24 hours after an oral dose. After a single dose of minocycline, the mean concentration of the drug in tear samples was 189 ± 58 ng/mL and corresponding plasma levels were 578 ± 290 ng/mL. In a second study, we monitored the pharmacokinetics of the drug in tear and plasma samples of healthy nonfasting adults. Tear and plasma samples were collected at 1 through 6, 12, 24, 48, 72, and 96 hours. The pharmacokinetics study revealed that 48 hours following a single 200-mg dose of minocycline, the mean tear level of minocycline was 68 ng/mL, which is above the in vitro minimal inhibitory concentration required for Chlamydia trachomatis and other susceptible organisms.
AB - We determined minocycline levels in human tears and plasma samples using high-performance liquid chromatography. In the first study, we determined the trough tear and plasma levels of minocycline in patients with active trachoma 24 hours after an oral dose. After a single dose of minocycline, the mean concentration of the drug in tear samples was 189 ± 58 ng/mL and corresponding plasma levels were 578 ± 290 ng/mL. In a second study, we monitored the pharmacokinetics of the drug in tear and plasma samples of healthy nonfasting adults. Tear and plasma samples were collected at 1 through 6, 12, 24, 48, 72, and 96 hours. The pharmacokinetics study revealed that 48 hours following a single 200-mg dose of minocycline, the mean tear level of minocycline was 68 ng/mL, which is above the in vitro minimal inhibitory concentration required for Chlamydia trachomatis and other susceptible organisms.
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U2 - 10.1001/archopht.1989.01070010095034
DO - 10.1001/archopht.1989.01070010095034
M3 - Article
C2 - 2910292
AN - SCOPUS:0024558817
SN - 0003-9950
VL - 107
SP - 93
EP - 95
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 1
ER -