@inproceedings{1a08057084d44dcd8265ba60fd295d59,
title = "Minimally invasive intraventricular ultrasound: Design and instrumentation towards a miniaturized ultrasound-guided focused ultrasound probe",
abstract = "Neurosurgery typically requires craniectomy and meticulous dissection to achieve sufficient exposure for subsequent surgical intervention. This highly invasive process requires hours of operating time, long recovery periods and leaves patients with visible surgical scars. Non-invasive high-intensity focused ultrasound (HIFU) has shown some promise yet remains challenged by the attenuation of ultrasonic waves while passing through the skull. Consequently, the clinical impact of this technology remains limited, particularly in the treatment of neuro-oncology. In order to compensate for acoustic attenuation, excessive use of power for HIFU devices has been investigated, although it is undesirable from a regulatory and patient safety standpoint. Here, we report the design and development of a novel HIFU device prototype for neurologic lesion ablation. This device concept is envisioned to access the ventricular space via a minimally invasive ventriculostomy, allowing ultrasound to reach targets deep in the brain, while eliminating the need for high power to penetrate the skull.",
keywords = "Focused Ultrasound, Instrumentation, Minimally Invasive Surgery, Neurosurgery, Oncology, Therapeutic Ultrasound, Ultrasound, Ventricles",
author = "Micah Belzberg and Francisco Chavez and Xiong, {Kah Timothy} and Kyle Morrison and Nao Gamo and Stephen Restaino and Rajiv Iyer and Mari Groves and Nitish Thakor and Henry Brem and Alan Cohen and Amir Manbachi",
note = "Funding Information: The authors are thankful to the following funding sources for this study: (i) TEDCO (Maryland Technology Development Corporation){\textquoteright}s MII (Maryland Innovation Initiative); (ii) Johns Hopkins - Coulter Foundation Translational partnership; (iii) Johns Hopkins University, Whiting School of Engineering{\textquoteright}s Cohen Translational funding; and (iv) National Science Foundation{\textquoteright}s I-CORPS grant No: 1853459. The authors would also like to thank Dr. Jeffrey H Siewerdsen (Johns Hopkins Biomedical Engineering) and Dr. Mark G. Luciano (Johns Hopkins Department of Neurosurgery, Cerebral Fluid Center) for fruitful discussions and support. Publisher Copyright: {\textcopyright} 2019 SPIE.; Medical Imaging 2019: Image-Guided Procedures, Robotic Interventions, and Modeling ; Conference date: 17-02-2019 Through 19-02-2019",
year = "2019",
doi = "10.1117/12.2513150",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Baowei Fei and Linte, {Cristian A.}",
booktitle = "Medical Imaging 2019",
}