Mimicking biological functionality with polymers for biomedical applications

Jordan J. Green; Jennifer H. Elisseeff

doi:10.1038/nature21005

Mimicking biological functionality with polymers for biomedical applications

Jordan J. Green, Jennifer H. Elisseeff

School of Medicine

Research output: Contribution to journal › Review article › peer-review

220 Scopus citations

Abstract

The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological understanding and engineering capabilities develop, more sophisticated biomedical materials can be synthesized that have multifaceted chemical, biological and physical characteristics designed to achieve specific therapeutic goals. Mimicry is being used in the design of polymers for biomedical applications that are required locally in tissues, systemically throughout the body, and at the interface with tissues.

Original language	English (US)
Pages (from-to)	386-394
Number of pages	9
Journal	Nature
Volume	540
Issue number	7633
DOIs	https://doi.org/10.1038/nature21005
State	Published - Dec 14 2016

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title = "Mimicking biological functionality with polymers for biomedical applications",

abstract = "The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological understanding and engineering capabilities develop, more sophisticated biomedical materials can be synthesized that have multifaceted chemical, biological and physical characteristics designed to achieve specific therapeutic goals. Mimicry is being used in the design of polymers for biomedical applications that are required locally in tissues, systemically throughout the body, and at the interface with tissues.",

author = "Green, {Jordan J.} and Elisseeff, {Jennifer H.}",

note = "Funding Information: The authors thank K. Sadtler for contributions and the design of Figs 1 and 4, C. Cherry for editorial assistance, and M. Frisk for critical review and manuscript contributions. J.J.G. was supported in part by the NIH (1R01EB016721). J.H.E. was supported by the Department of Defense including the Armed Forces Institute of Regenerative Medicine Publisher Copyright: {\textcopyright} 2016 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.",

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N2 - The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological understanding and engineering capabilities develop, more sophisticated biomedical materials can be synthesized that have multifaceted chemical, biological and physical characteristics designed to achieve specific therapeutic goals. Mimicry is being used in the design of polymers for biomedical applications that are required locally in tissues, systemically throughout the body, and at the interface with tissues.

AB - The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological understanding and engineering capabilities develop, more sophisticated biomedical materials can be synthesized that have multifaceted chemical, biological and physical characteristics designed to achieve specific therapeutic goals. Mimicry is being used in the design of polymers for biomedical applications that are required locally in tissues, systemically throughout the body, and at the interface with tissues.

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Mimicking biological functionality with polymers for biomedical applications

Abstract

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