Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction

Raffaele Antonelli Incalzi; Vincenzo Bellia; Stefania Maggi; Claudio Imperiale; Oliviero Capparella; Filippo Catalano; Pier Ugo Carbonin; Franco Rengo; D. L. Consales; D. Lo Nardo; P. Paggi; F. Goria; P. Fea; G. Iraldi; R. Corradi; A. Capurso; R. Flora; S. Torres; G. Venezia; M. Mesto; S. Semeraro; L. Belloti; A. Tansella; V. Grassi; S. Cossi; G. Guerini; C. Fantoni; M. De Martinis; L. Pini; G. Melillo; R. Battiloro; C. Gaudiosi; S. De Angelis; L. Motta; I. Alessandria; S. Savia; G. Masotti; M. Chiarlone; S. Zacchei; V. Pedone; D. Angelini; D. Cilla; E. Palummeri; M. Agretti; P. Costelli; D. Torriglia; M. Trabucchi; P. Barbisoni; F. Guerini; P. Ranieri; F. Caione; D. Caione; M. La Chiara; G. Galetti; A. Cantatore; D. Casarotti; G. Anni; F. Cacciatore; A. I. Pisacreta; C. Calabrese; G. Enzi; P. Dalla Montà; S. Peruzza; P. Albanese; F. Tiozzo; D. Olivieri; V. Bocchino; A. Comel; N. Barbarito; U. Senin; F. Amone; L. Camilli; S. Peretti; S. M. Zuccaro; M. Marchetti; L. Palleschi; M. Palleschi; C. Cieri; F. Vetta; F. Pagano; P. Ranieri; C. Romano; S. Forconi; G. Abate; G. Marotta; E. Pagni; C. Spada; C. Vergani; G. Giardini; M. C. Sandrini; I. Dallera; N. Scichilone; S. Battaglia

doi:10.1007/BF03324468

Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction

Raffaele Antonelli Incalzi, Vincenzo Bellia, Stefania Maggi, Claudio Imperiale, Oliviero Capparella, Filippo Catalano, Pier Ugo Carbonin, Franco Rengo, D. L. Consales, D. Lo Nardo, P. Paggi, F. Goria, P. Fea, G. Iraldi, R. Corradi, A. Capurso, R. Flora, S. Torres, G. Venezia, M. MestoS. Semeraro, L. Belloti, A. Tansella, V. Grassi, S. Cossi, G. Guerini, C. Fantoni, M. De Martinis, L. Pini, G. Melillo, R. Battiloro, C. Gaudiosi, S. De Angelis, L. Motta, I. Alessandria, S. Savia, G. Masotti, M. Chiarlone, S. Zacchei, V. Pedone, D. Angelini, D. Cilla, E. Palummeri, M. Agretti, P. Costelli, D. Torriglia, M. Trabucchi, P. Barbisoni, F. Guerini, P. Ranieri, F. Caione, D. Caione, M. La Chiara, G. Galetti, A. Cantatore, D. Casarotti, G. Anni, F. Cacciatore, A. I. Pisacreta, C. Calabrese, G. Enzi, P. Dalla Montà, S. Peruzza, P. Albanese, F. Tiozzo, D. Olivieri, V. Bocchino, A. Comel, N. Barbarito, U. Senin, F. Amone, L. Camilli, S. Peretti, S. M. Zuccaro, M. Marchetti, L. Palleschi, M. Palleschi, C. Cieri, F. Vetta, F. Pagano, P. Ranieri, C. Romano, S. Forconi, G. Abate, G. Marotta, E. Pagni, C. Spada, C. Vergani, G. Giardini, M. C. Sandrini, I. Dallera, N. Scichilone, S. Battaglia

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Background and aims: Whether chronic obstructive pulmonary disease (COPD) carries a risk of cognitive dysfunction prior to the onset of arterial hypoxemia is not known. Our objective was to assess both the prevalence and main correlates of subclinical cognitive dysfunction in older patients with non-hypoxemic COPD. Methods: Home-dwelling non-demented subjects over 64 years of age consecutively attending 24 outpatient Departments of Respiratory Medicine or Geriatrics because of COPD (N=233), asthma (N=203), non-obstructive bronchitis (N=92) or chronic non-respiratory and non-dementing diseases (controls, N=1080) underwent a multidimensional assessment. Cognitive status was assessed by the Mini-Mental State Examination (MMSE). Independent correlates of MMSE<24 were identified by logistic regression analysis. In order to limit the confounding effect of collinearity between COPD group membership and the 6' walked distance, a properly designed multivariate analysis was performed. Results: Prevalence of MMSE<24 ranged from 16.7% (controls) to 21.9% (COPD). Education <9 years (Odds Ratio=1.56, Confidence Intervals=1.22-1.98), a score >6 on the 15-item Geriatric Depression Scale (OR=1.37, CI=1.16-1.62), a 6' walked distance <242 m (OR=1.22, CI=1.02-1.45), a Barthel Index greater than 80 (OR=1.48, CI=1.03-2.14) and a Forced Vital Capacity inferior to 80% of the predicted value (OR=1.17, CI=1.09-1.38) qualified as independent correlates of MMSE<24. The multivariate analysis confirmed that groups had comparable MMSE scores. Conclusions: Non-hypoxemic COPD did not increase the risk of subclinical cognitive dysfunction in an older population.

Original language	English (US)
Pages (from-to)	395-401
Number of pages	7
Journal	Aging Clinical and Experimental Research
Volume	14
Issue number	5
DOIs	https://doi.org/10.1007/BF03324468
State	Published - Oct 2002
Externally published	Yes

Keywords

Asthma
COPD
Cognitive impairment
Elderly
MMSE
Respiratory function

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1007/BF03324468

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Incalzi, R. A., Bellia, V., Maggi, S., Imperiale, C., Capparella, O., Catalano, F., Carbonin, P. U., Rengo, F., Consales, D. L., Lo Nardo, D., Paggi, P., Goria, F., Fea, P., Iraldi, G., Corradi, R., Capurso, A., Flora, R., Torres, S., Venezia, G., ... Battaglia, S. (2002). Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction. Aging Clinical and Experimental Research, 14(5), 395-401. https://doi.org/10.1007/BF03324468

Incalzi, RA, Bellia, V, Maggi, S, Imperiale, C, Capparella, O, Catalano, F, Carbonin, PU, Rengo, F, Consales, DL, Lo Nardo, D, Paggi, P, Goria, F, Fea, P, Iraldi, G, Corradi, R, Capurso, A, Flora, R, Torres, S, Venezia, G, Mesto, M, Semeraro, S, Belloti, L, Tansella, A, Grassi, V, Cossi, S, Guerini, G, Fantoni, C, De Martinis, M, Pini, L, Melillo, G, Battiloro, R, Gaudiosi, C, De Angelis, S, Motta, L, Alessandria, I, Savia, S, Masotti, G, Chiarlone, M, Zacchei, S, Pedone, V, Angelini, D, Cilla, D, Palummeri, E, Agretti, M, Costelli, P, Torriglia, D, Trabucchi, M, Barbisoni, P, Guerini, F, Ranieri, P, Caione, F, Caione, D, La Chiara, M, Galetti, G, Cantatore, A, Casarotti, D, Anni, G, Cacciatore, F, Pisacreta, AI, Calabrese, C, Enzi, G, Dalla Montà, P, Peruzza, S, Albanese, P, Tiozzo, F, Olivieri, D, Bocchino, V, Comel, A, Barbarito, N, Senin, U, Amone, F, Camilli, L, Peretti, S, Zuccaro, SM, Marchetti, M, Palleschi, L, Palleschi, M, Cieri, C, Vetta, F, Pagano, F, Ranieri, P, Romano, C, Forconi, S, Abate, G, Marotta, G, Pagni, E, Spada, C, Vergani, C, Giardini, G, Sandrini, MC, Dallera, I, Scichilone, N & Battaglia, S 2002, 'Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction', Aging Clinical and Experimental Research, vol. 14, no. 5, pp. 395-401. https://doi.org/10.1007/BF03324468

@article{2d4d96448e524b708ed03310c8f04ef8,

title = "Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction",

abstract = "Background and aims: Whether chronic obstructive pulmonary disease (COPD) carries a risk of cognitive dysfunction prior to the onset of arterial hypoxemia is not known. Our objective was to assess both the prevalence and main correlates of subclinical cognitive dysfunction in older patients with non-hypoxemic COPD. Methods: Home-dwelling non-demented subjects over 64 years of age consecutively attending 24 outpatient Departments of Respiratory Medicine or Geriatrics because of COPD (N=233), asthma (N=203), non-obstructive bronchitis (N=92) or chronic non-respiratory and non-dementing diseases (controls, N=1080) underwent a multidimensional assessment. Cognitive status was assessed by the Mini-Mental State Examination (MMSE). Independent correlates of MMSE<24 were identified by logistic regression analysis. In order to limit the confounding effect of collinearity between COPD group membership and the 6' walked distance, a properly designed multivariate analysis was performed. Results: Prevalence of MMSE<24 ranged from 16.7% (controls) to 21.9% (COPD). Education <9 years (Odds Ratio=1.56, Confidence Intervals=1.22-1.98), a score >6 on the 15-item Geriatric Depression Scale (OR=1.37, CI=1.16-1.62), a 6' walked distance <242 m (OR=1.22, CI=1.02-1.45), a Barthel Index greater than 80 (OR=1.48, CI=1.03-2.14) and a Forced Vital Capacity inferior to 80% of the predicted value (OR=1.17, CI=1.09-1.38) qualified as independent correlates of MMSE<24. The multivariate analysis confirmed that groups had comparable MMSE scores. Conclusions: Non-hypoxemic COPD did not increase the risk of subclinical cognitive dysfunction in an older population.",

keywords = "Asthma, COPD, Cognitive impairment, Elderly, MMSE, Respiratory function",

author = "Incalzi, {Raffaele Antonelli} and Vincenzo Bellia and Stefania Maggi and Claudio Imperiale and Oliviero Capparella and Filippo Catalano and Carbonin, {Pier Ugo} and Franco Rengo and Consales, {D. L.} and {Lo Nardo}, D. and P. Paggi and F. Goria and P. Fea and G. Iraldi and R. Corradi and A. Capurso and R. Flora and S. Torres and G. Venezia and M. Mesto and S. Semeraro and L. Belloti and A. Tansella and V. Grassi and S. Cossi and G. Guerini and C. Fantoni and {De Martinis}, M. and L. Pini and G. Melillo and R. Battiloro and C. Gaudiosi and {De Angelis}, S. and L. Motta and I. Alessandria and S. Savia and G. Masotti and M. Chiarlone and S. Zacchei and V. Pedone and D. Angelini and D. Cilla and E. Palummeri and M. Agretti and P. Costelli and D. Torriglia and M. Trabucchi and P. Barbisoni and F. Guerini and P. Ranieri and F. Caione and D. Caione and {La Chiara}, M. and G. Galetti and A. Cantatore and D. Casarotti and G. Anni and F. Cacciatore and Pisacreta, {A. I.} and C. Calabrese and G. Enzi and {Dalla Mont{\`a}}, P. and S. Peruzza and P. Albanese and F. Tiozzo and D. Olivieri and V. Bocchino and A. Comel and N. Barbarito and U. Senin and F. Amone and L. Camilli and S. Peretti and Zuccaro, {S. M.} and M. Marchetti and L. Palleschi and M. Palleschi and C. Cieri and F. Vetta and F. Pagano and P. Ranieri and C. Romano and S. Forconi and G. Abate and G. Marotta and E. Pagni and C. Spada and C. Vergani and G. Giardini and Sandrini, {M. C.} and I. Dallera and N. Scichilone and S. Battaglia",

note = "Funding Information: The Sa.R.A. Study was supported by a research grant from Boehringer Ingelheim Italia, that is gratefully acknowledged. All participants are indebted to G. Torresin and the staff of Biomedin (Padova, Italy) for their continuous and dedicated technical assistance.",

year = "2002",

month = oct,

doi = "10.1007/BF03324468",

language = "English (US)",

volume = "14",

pages = "395--401",

journal = "Aging Clinical and Experimental Research",

issn = "1594-0667",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "5",

}

TY - JOUR

T1 - Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction

AU - Incalzi, Raffaele Antonelli

AU - Bellia, Vincenzo

AU - Maggi, Stefania

AU - Imperiale, Claudio

AU - Capparella, Oliviero

AU - Catalano, Filippo

AU - Carbonin, Pier Ugo

AU - Rengo, Franco

AU - Consales, D. L.

AU - Lo Nardo, D.

AU - Paggi, P.

AU - Goria, F.

AU - Fea, P.

AU - Iraldi, G.

AU - Corradi, R.

AU - Capurso, A.

AU - Flora, R.

AU - Torres, S.

AU - Venezia, G.

AU - Mesto, M.

AU - Semeraro, S.

AU - Belloti, L.

AU - Tansella, A.

AU - Grassi, V.

AU - Cossi, S.

AU - Guerini, G.

AU - Fantoni, C.

AU - De Martinis, M.

AU - Pini, L.

AU - Melillo, G.

AU - Battiloro, R.

AU - Gaudiosi, C.

AU - De Angelis, S.

AU - Motta, L.

AU - Alessandria, I.

AU - Savia, S.

AU - Masotti, G.

AU - Chiarlone, M.

AU - Zacchei, S.

AU - Pedone, V.

AU - Angelini, D.

AU - Cilla, D.

AU - Palummeri, E.

AU - Agretti, M.

AU - Costelli, P.

AU - Torriglia, D.

AU - Trabucchi, M.

AU - Barbisoni, P.

AU - Guerini, F.

AU - Ranieri, P.

AU - Caione, F.

AU - Caione, D.

AU - La Chiara, M.

AU - Galetti, G.

AU - Cantatore, A.

AU - Casarotti, D.

AU - Anni, G.

AU - Cacciatore, F.

AU - Pisacreta, A. I.

AU - Calabrese, C.

AU - Enzi, G.

AU - Dalla Montà, P.

AU - Peruzza, S.

AU - Albanese, P.

AU - Tiozzo, F.

AU - Olivieri, D.

AU - Bocchino, V.

AU - Comel, A.

AU - Barbarito, N.

AU - Senin, U.

AU - Amone, F.

AU - Camilli, L.

AU - Peretti, S.

AU - Zuccaro, S. M.

AU - Marchetti, M.

AU - Palleschi, L.

AU - Palleschi, M.

AU - Cieri, C.

AU - Vetta, F.

AU - Pagano, F.

AU - Ranieri, P.

AU - Romano, C.

AU - Forconi, S.

AU - Abate, G.

AU - Marotta, G.

AU - Pagni, E.

AU - Spada, C.

AU - Vergani, C.

AU - Giardini, G.

AU - Sandrini, M. C.

AU - Dallera, I.

AU - Scichilone, N.

AU - Battaglia, S.

N1 - Funding Information: The Sa.R.A. Study was supported by a research grant from Boehringer Ingelheim Italia, that is gratefully acknowledged. All participants are indebted to G. Torresin and the staff of Biomedin (Padova, Italy) for their continuous and dedicated technical assistance.

PY - 2002/10

Y1 - 2002/10

N2 - Background and aims: Whether chronic obstructive pulmonary disease (COPD) carries a risk of cognitive dysfunction prior to the onset of arterial hypoxemia is not known. Our objective was to assess both the prevalence and main correlates of subclinical cognitive dysfunction in older patients with non-hypoxemic COPD. Methods: Home-dwelling non-demented subjects over 64 years of age consecutively attending 24 outpatient Departments of Respiratory Medicine or Geriatrics because of COPD (N=233), asthma (N=203), non-obstructive bronchitis (N=92) or chronic non-respiratory and non-dementing diseases (controls, N=1080) underwent a multidimensional assessment. Cognitive status was assessed by the Mini-Mental State Examination (MMSE). Independent correlates of MMSE<24 were identified by logistic regression analysis. In order to limit the confounding effect of collinearity between COPD group membership and the 6' walked distance, a properly designed multivariate analysis was performed. Results: Prevalence of MMSE<24 ranged from 16.7% (controls) to 21.9% (COPD). Education <9 years (Odds Ratio=1.56, Confidence Intervals=1.22-1.98), a score >6 on the 15-item Geriatric Depression Scale (OR=1.37, CI=1.16-1.62), a 6' walked distance <242 m (OR=1.22, CI=1.02-1.45), a Barthel Index greater than 80 (OR=1.48, CI=1.03-2.14) and a Forced Vital Capacity inferior to 80% of the predicted value (OR=1.17, CI=1.09-1.38) qualified as independent correlates of MMSE<24. The multivariate analysis confirmed that groups had comparable MMSE scores. Conclusions: Non-hypoxemic COPD did not increase the risk of subclinical cognitive dysfunction in an older population.

AB - Background and aims: Whether chronic obstructive pulmonary disease (COPD) carries a risk of cognitive dysfunction prior to the onset of arterial hypoxemia is not known. Our objective was to assess both the prevalence and main correlates of subclinical cognitive dysfunction in older patients with non-hypoxemic COPD. Methods: Home-dwelling non-demented subjects over 64 years of age consecutively attending 24 outpatient Departments of Respiratory Medicine or Geriatrics because of COPD (N=233), asthma (N=203), non-obstructive bronchitis (N=92) or chronic non-respiratory and non-dementing diseases (controls, N=1080) underwent a multidimensional assessment. Cognitive status was assessed by the Mini-Mental State Examination (MMSE). Independent correlates of MMSE<24 were identified by logistic regression analysis. In order to limit the confounding effect of collinearity between COPD group membership and the 6' walked distance, a properly designed multivariate analysis was performed. Results: Prevalence of MMSE<24 ranged from 16.7% (controls) to 21.9% (COPD). Education <9 years (Odds Ratio=1.56, Confidence Intervals=1.22-1.98), a score >6 on the 15-item Geriatric Depression Scale (OR=1.37, CI=1.16-1.62), a 6' walked distance <242 m (OR=1.22, CI=1.02-1.45), a Barthel Index greater than 80 (OR=1.48, CI=1.03-2.14) and a Forced Vital Capacity inferior to 80% of the predicted value (OR=1.17, CI=1.09-1.38) qualified as independent correlates of MMSE<24. The multivariate analysis confirmed that groups had comparable MMSE scores. Conclusions: Non-hypoxemic COPD did not increase the risk of subclinical cognitive dysfunction in an older population.

KW - Asthma

KW - COPD

KW - Cognitive impairment

KW - Elderly

KW - MMSE

KW - Respiratory function

UR - http://www.scopus.com/inward/record.url?scp=0037739780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037739780&partnerID=8YFLogxK

U2 - 10.1007/BF03324468

DO - 10.1007/BF03324468

M3 - Article

C2 - 12602575

AN - SCOPUS:0037739780

SN - 1594-0667

VL - 14

SP - 395

EP - 401

JO - Aging Clinical and Experimental Research

JF - Aging Clinical and Experimental Research

IS - 5

ER -

Mild to moderate chronic airways disease does not carry an excess risk of cognitive dysfunction

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