Mild nitrosation and hydrolysis of polyfunctional amides

David A. Evans, Percy H. Carter, Christopher J. Dinsmore, James C. Barrow, Jeffrey L. Katz, Daniel W. Kung

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Secondary amides may he hydrolyzed via a mild, high-yielding sequence consisting of N-nitrosation, treatment with lithium hydroperoxide, and reduction with sodium sulfite. These operations may be executed in the presence of an army of functional groups, including other amide functionality.

Original languageEnglish (US)
Pages (from-to)4535-4538
Number of pages4
JournalTetrahedron Letters
Issue number26
StatePublished - Jun 30 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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