TY - JOUR
T1 - Midbrain dopamine and prefrontal function in humans
T2 - Interaction and modulation by COMT genotype
AU - Meyer-Lindenberg, Andreas
AU - Kohn, Philip D.
AU - Kolachana, Bhaskar
AU - Kippenhan, Shane
AU - McInerney-Leo, Aideen
AU - Nussbaum, Robert
AU - Weinberger, Daniel R.
AU - Berman, Karen Faith
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2005/5
Y1 - 2005/5
N2 - Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O- methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopamine synthesis in midbrain and qualitatively affected the interaction with prefrontal cortex. These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT.
AB - Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O- methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopamine synthesis in midbrain and qualitatively affected the interaction with prefrontal cortex. These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT.
UR - http://www.scopus.com/inward/record.url?scp=17844368319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17844368319&partnerID=8YFLogxK
U2 - 10.1038/nn1438
DO - 10.1038/nn1438
M3 - Article
C2 - 15821730
AN - SCOPUS:17844368319
SN - 1097-6256
VL - 8
SP - 594
EP - 596
JO - Nature neuroscience
JF - Nature neuroscience
IS - 5
ER -