Microwave-assisted and scandium triflate catalyzed synthesis of tetrahydrobenzo[a]xanthen-11-ones

Madharam Sudershan Rao, Bhupender S. Chhikara, Rakesh Tiwari, Amir N. Shirazi, Keykavous Parang, Anil Kumar

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Synthesis of 12-aryl-8,9,10,12-tetrahydro-benzo[fl]xanthen-11-ones was achieved by one-pot condensation of β-naphthol, substituted benzaldehydes, and 1,3-dicarbonyl compounds catalyzed by Sc(OTf) 3 under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity.

Original languageEnglish (US)
Pages (from-to)263-268
Number of pages6
JournalMonatshefte fur Chemie
Issue number2
StatePublished - Feb 2012
Externally publishedYes


  • Anticancer
  • Lewis acids
  • Microwave-assisted synthesis
  • Multi-component reaction
  • Solvent-free
  • Src kinase activity

ASJC Scopus subject areas

  • Chemistry(all)


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