TY - JOUR
T1 - Microwave-assisted and scandium triflate catalyzed synthesis of tetrahydrobenzo[a]xanthen-11-ones
AU - Rao, Madharam Sudershan
AU - Chhikara, Bhupender S.
AU - Tiwari, Rakesh
AU - Shirazi, Amir N.
AU - Parang, Keykavous
AU - Kumar, Anil
PY - 2012/2
Y1 - 2012/2
N2 - Synthesis of 12-aryl-8,9,10,12-tetrahydro-benzo[fl]xanthen-11-ones was achieved by one-pot condensation of β-naphthol, substituted benzaldehydes, and 1,3-dicarbonyl compounds catalyzed by Sc(OTf) 3 under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity.
AB - Synthesis of 12-aryl-8,9,10,12-tetrahydro-benzo[fl]xanthen-11-ones was achieved by one-pot condensation of β-naphthol, substituted benzaldehydes, and 1,3-dicarbonyl compounds catalyzed by Sc(OTf) 3 under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity.
KW - Anticancer
KW - Lewis acids
KW - Microwave-assisted synthesis
KW - Multi-component reaction
KW - Solvent-free
KW - Src kinase activity
UR - http://www.scopus.com/inward/record.url?scp=84858861423&partnerID=8YFLogxK
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U2 - 10.1007/s00706-011-0577-4
DO - 10.1007/s00706-011-0577-4
M3 - Article
AN - SCOPUS:84858861423
SN - 0026-9247
VL - 143
SP - 263
EP - 268
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
IS - 2
ER -