Microstructure of trabecular bone in a mouse model for down syndrome

Trish Parsons, Timothy M. Ryan, Roger H. Reeves, Joan T. Richtsmeier

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21) and results in a suite of dysmorphic phenotypes, including effects on the postcranial skeleton and the skull. We have previously demonstrated parallels in the patterns of craniofacial dysmorphology in DS and in the Ts65Dn mouse model for DS. The specific mechanisms underlying the production of these changes in craniofacial shape remain unknown. High-resolution computed tomography scan data were collected for the presphenoid bone of euploid and aneuploid mice. Three-dimensional morphometric parameters of trabecular bone were quantified and compared between euploid and aneuploid mice using nonparametric statistical tests. Aneuploid presphenoid bones were smaller than those of their euploid littermates and had lower bone volume fraction and fewer, more rod-like trabeculae. The differences in cancellous bone structure suggest that bone development, perhaps including bone modeling and remodeling, is affected by aneuploidy. These differences may contribute to the observed dysmorphology of skull and postcranial skeletal phenotypes in DS.

Original languageEnglish (US)
Pages (from-to)414-421
Number of pages8
JournalAnatomical Record
Issue number4
StatePublished - Apr 2007


  • Aneuploidy
  • Down syndrome
  • High-resolution microcomputed tomography
  • Mouse model
  • Presphenoid bone
  • Trabecular bone
  • Trisomy 21

ASJC Scopus subject areas

  • Anatomy
  • Biotechnology
  • Histology
  • Ecology, Evolution, Behavior and Systematics


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