Microstructural analysis of synergistic interactions in the control of meal size

T. H. Moran; G. J. Schwartz

doi:10.1016/S0195-6663(95)80070-0

Microstructural analysis of synergistic interactions in the control of meal size

T. H. Moran, G. J. Schwartz

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Recent work in the control of ingestive behavior has focussed on the role of signals arising from peripheral sites that are stimulated by the nutrient products of ingestion. During real feeding, it is the constellation of simultaneous peripheral signals that determine short term intake. Thus, the feeding inhibitory action of CCK is enhanced in the presence of an intragastric saline load. Equivalent reductions in short term feeding over a fixed time period may result from different microstructural patterns of ingestive behavior. Differences in the microstructure of ingestion reflect differential central or peripheral processing of physiological signals. We compared patterns of ingestion in response to individual or combined meal related stimuli that reduce liquid food intake by tracking the occurrence of each lick during ingestion of a liquid test meal. Equivalent 30-min intakes are obtained following a high dose of a CCK analog alone or from a low dose in combination with a gastric saline preload. However, the patterns of licking that generate these equivalent intake volumes differ.

Original language	English (US)
Pages (from-to)	88-89
Number of pages	2
Journal	Appetite
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/S0195-6663(95)80070-0
State	Published - 1995

ASJC Scopus subject areas

General Psychology
Nutrition and Dietetics

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10.1016/S0195-6663(95)80070-0

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title = "Microstructural analysis of synergistic interactions in the control of meal size",

abstract = "Recent work in the control of ingestive behavior has focussed on the role of signals arising from peripheral sites that are stimulated by the nutrient products of ingestion. During real feeding, it is the constellation of simultaneous peripheral signals that determine short term intake. Thus, the feeding inhibitory action of CCK is enhanced in the presence of an intragastric saline load. Equivalent reductions in short term feeding over a fixed time period may result from different microstructural patterns of ingestive behavior. Differences in the microstructure of ingestion reflect differential central or peripheral processing of physiological signals. We compared patterns of ingestion in response to individual or combined meal related stimuli that reduce liquid food intake by tracking the occurrence of each lick during ingestion of a liquid test meal. Equivalent 30-min intakes are obtained following a high dose of a CCK analog alone or from a low dose in combination with a gastric saline preload. However, the patterns of licking that generate these equivalent intake volumes differ.",

author = "Moran, {T. H.} and Schwartz, {G. J.}",

note = "Funding Information: Dietary sodium deprivation induces salt appetite and alters the responsiveness of gustatory neurons to NaC1 solutions. We replicated this experiment while recording from the nucleus of the solitary tract of chronically prepared rats using diet, diuretic, or a hormone to raise the appetite. As in previous experiments, dietary deprivation reduced the response magnitude of NaCl-best taste neurons but, unlike in those reports, the effect was relatively non-specific. The mean response to NaCI, sucrose, citric acid, and quinine all decreased by roughly the same amount (range 41-84%). In addition, the mean responses of sucrose-best cells also were reduced. When we used a diuretic, furosemide, to induce an appetite in a similar preparation, NaCI-best neurons responded more, rather than less, and the effect was specific to NaCI. Intraventricular injections of renin also induce salt appetite. This regimen resulted in a modest reduction in the response of NaCl-best neurons to NaCI, but only at higher concentrations (0-3 and l-0ra). (Supported by NIH MH 3787, DC 00240, and MH 00653.)",

year = "1995",

doi = "10.1016/S0195-6663(95)80070-0",

language = "English (US)",

volume = "24",

pages = "88--89",

journal = "Appetite",

issn = "0195-6663",

publisher = "Academic Press Inc.",

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T1 - Microstructural analysis of synergistic interactions in the control of meal size

AU - Moran, T. H.

AU - Schwartz, G. J.

N1 - Funding Information: Dietary sodium deprivation induces salt appetite and alters the responsiveness of gustatory neurons to NaC1 solutions. We replicated this experiment while recording from the nucleus of the solitary tract of chronically prepared rats using diet, diuretic, or a hormone to raise the appetite. As in previous experiments, dietary deprivation reduced the response magnitude of NaCl-best taste neurons but, unlike in those reports, the effect was relatively non-specific. The mean response to NaCI, sucrose, citric acid, and quinine all decreased by roughly the same amount (range 41-84%). In addition, the mean responses of sucrose-best cells also were reduced. When we used a diuretic, furosemide, to induce an appetite in a similar preparation, NaCI-best neurons responded more, rather than less, and the effect was specific to NaCI. Intraventricular injections of renin also induce salt appetite. This regimen resulted in a modest reduction in the response of NaCl-best neurons to NaCI, but only at higher concentrations (0-3 and l-0ra). (Supported by NIH MH 3787, DC 00240, and MH 00653.)

PY - 1995

Y1 - 1995

N2 - Recent work in the control of ingestive behavior has focussed on the role of signals arising from peripheral sites that are stimulated by the nutrient products of ingestion. During real feeding, it is the constellation of simultaneous peripheral signals that determine short term intake. Thus, the feeding inhibitory action of CCK is enhanced in the presence of an intragastric saline load. Equivalent reductions in short term feeding over a fixed time period may result from different microstructural patterns of ingestive behavior. Differences in the microstructure of ingestion reflect differential central or peripheral processing of physiological signals. We compared patterns of ingestion in response to individual or combined meal related stimuli that reduce liquid food intake by tracking the occurrence of each lick during ingestion of a liquid test meal. Equivalent 30-min intakes are obtained following a high dose of a CCK analog alone or from a low dose in combination with a gastric saline preload. However, the patterns of licking that generate these equivalent intake volumes differ.

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Microstructural analysis of synergistic interactions in the control of meal size

Abstract

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