@article{8bfdb574148040f88a4bf4fec8ce28b6,
title = "Microsomal interactions and inhibition of lipid peroxidation by etoposide (VP-16, 213): Implications for mode of action",
author = "Sinha, \{Birandra K.\} and Trush, \{Michael A.\} and Balaraman and Kalyanaraman",
note = "Funding Information: Also, it could be demonstrated that compounds which are changes in the characteristics of the Padrenergic receptors structurally related to catecholamines, such pyrocatechol and of the number and distribution of the cY-adrenergic and 3,4\_dihydroxymandelic acid, but devoid of padre-receptors in relation to the lactation cycle are now in nergic activity, did not compete for the binding sites. At progress in order to establish their role in the process of 1 mM concentration, these compounds inhibited the bind-lactogenesis. ing of ( -)-[3H]DHA to mammary membranes by less than 6.6 and 17.2\% respectively. Acknowledgemenrs-This work was supported by Grant Finally, a functional response to mammary Padrenergic B 1138-8333 from the Department0 de Desarrollo de la receptor triggering was verified by measuring the increase Investigation, Universidad de Chile. We are indebted to of cyclic AMP production after isoproterenol stimulation of Prof. A. L. Greenbaum, University College London, for adenylate cyclase in lactating mammary gland membranes his help in the preparation of this manuscript. (Fig. 3). These experiments confirmed the inhibition of lactose production by epinephrine, isoproterenol and dibu-Departamento de Bioquimica tyryl cyclic AMP, reported by Loizzi er al. [l]. Facultad de Ciencias Bkcas y Farmactkticas Universidad de Chile Casilla 233, Santiago, Chile",
year = "1985",
month = jun,
day = "1",
doi = "10.1016/0006-2952(85)90331-4",
language = "English (US)",
volume = "34",
pages = "2036--2040",
journal = "Biochemical Pharmacology",
issn = "0006-2952",
publisher = "Elsevier Inc.",
number = "11",
}