Microsatellite Instability Is Infrequent in Neuroblastoma

Patricia E. Berg; Jinbo Liu; Christopher N. Frantz; Jing Yin; Mun Gan Rhyu; Stephen J. Meitzer

Microsatellite Instability Is Infrequent in Neuroblastoma

Patricia E. Berg, Jinbo Liu, Christopher N. Frantz, Jing Yin, Mun Gan Rhyu, Stephen J. Meitzer

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Abstract

Neuroblastoma (NB) is a childhood cancer of the autonomic nervous System. The molecular pathology of NB is not yet well understood. Both amplification of the proto-oncogene N-myc and loss of heterozygosity of several chromosomal loci occur in NB, representing genetic instability. In this study, we examined another type of genetic instability, microsatellite instability. Five chromosomal loci known to exhibit this alteration in colon, gastric, and pancreatic cancers were used in a PCR-based assay to examine 30 matched normal and tumor DNAs, which included all stages of tumor Progression. Among these 30, only 2 (7%) manifested microsatellite instability. There was no correlation between the occurrence of microsatellite instability and the amplification of the N-myc gene. These data show that microsatellite instability is infrequent in neuroblastoma tumors.

Original language	English (US)
Pages (from-to)	907-909
Number of pages	3
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	4
Issue number	8
State	Published - Dec 1 1995
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Oncology

Cite this

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title = "Microsatellite Instability Is Infrequent in Neuroblastoma",

abstract = "Neuroblastoma (NB) is a childhood cancer of the autonomic nervous System. The molecular pathology of NB is not yet well understood. Both amplification of the proto-oncogene N-myc and loss of heterozygosity of several chromosomal loci occur in NB, representing genetic instability. In this study, we examined another type of genetic instability, microsatellite instability. Five chromosomal loci known to exhibit this alteration in colon, gastric, and pancreatic cancers were used in a PCR-based assay to examine 30 matched normal and tumor DNAs, which included all stages of tumor Progression. Among these 30, only 2 (7%) manifested microsatellite instability. There was no correlation between the occurrence of microsatellite instability and the amplification of the N-myc gene. These data show that microsatellite instability is infrequent in neuroblastoma tumors.",

author = "Berg, {Patricia E.} and Jinbo Liu and Frantz, {Christopher N.} and Jing Yin and Rhyu, {Mun Gan} and Meitzer, {Stephen J.}",

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T1 - Microsatellite Instability Is Infrequent in Neuroblastoma

AU - Berg, Patricia E.

AU - Liu, Jinbo

AU - Frantz, Christopher N.

AU - Yin, Jing

AU - Rhyu, Mun Gan

AU - Meitzer, Stephen J.

PY - 1995/12/1

Y1 - 1995/12/1

N2 - Neuroblastoma (NB) is a childhood cancer of the autonomic nervous System. The molecular pathology of NB is not yet well understood. Both amplification of the proto-oncogene N-myc and loss of heterozygosity of several chromosomal loci occur in NB, representing genetic instability. In this study, we examined another type of genetic instability, microsatellite instability. Five chromosomal loci known to exhibit this alteration in colon, gastric, and pancreatic cancers were used in a PCR-based assay to examine 30 matched normal and tumor DNAs, which included all stages of tumor Progression. Among these 30, only 2 (7%) manifested microsatellite instability. There was no correlation between the occurrence of microsatellite instability and the amplification of the N-myc gene. These data show that microsatellite instability is infrequent in neuroblastoma tumors.

AB - Neuroblastoma (NB) is a childhood cancer of the autonomic nervous System. The molecular pathology of NB is not yet well understood. Both amplification of the proto-oncogene N-myc and loss of heterozygosity of several chromosomal loci occur in NB, representing genetic instability. In this study, we examined another type of genetic instability, microsatellite instability. Five chromosomal loci known to exhibit this alteration in colon, gastric, and pancreatic cancers were used in a PCR-based assay to examine 30 matched normal and tumor DNAs, which included all stages of tumor Progression. Among these 30, only 2 (7%) manifested microsatellite instability. There was no correlation between the occurrence of microsatellite instability and the amplification of the N-myc gene. These data show that microsatellite instability is infrequent in neuroblastoma tumors.

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Microsatellite Instability Is Infrequent in Neuroblastoma

Abstract

ASJC Scopus subject areas

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