MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma

Takatsugu Kan; Stephen J. Meltzer

doi:10.1016/j.coph.2009.08.009

MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma

Takatsugu Kan
, Stephen J. Meltzer

School of Medicine

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.

Original language	English (US)
Pages (from-to)	727-732
Number of pages	6
Journal	Current Opinion in Pharmacology
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/j.coph.2009.08.009
State	Published - Dec 2009

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1016/j.coph.2009.08.009

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title = "MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma",

abstract = "The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.",

author = "Takatsugu Kan and Meltzer, \{Stephen J.\}",

note = "Funding Information: This work was supported partially by NIH awards CA085069, CA01808, and CA146799.",

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T1 - MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma

AU - Kan, Takatsugu

AU - Meltzer, Stephen J.

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PY - 2009/12

Y1 - 2009/12

N2 - The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.

AB - The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.

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DO - 10.1016/j.coph.2009.08.009

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MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma

Abstract

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