TY - JOUR
T1 - MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma
AU - Kan, Takatsugu
AU - Meltzer, Stephen J.
N1 - Funding Information:
This work was supported partially by NIH awards CA085069, CA01808, and CA146799.
PY - 2009/12
Y1 - 2009/12
N2 - The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.
AB - The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. Recent findings include the following: firstly, miRNA expression profiles can distinguish between BE and EAC; secondly, miR-196a is upregulated in EAC tissues targeting annexin A1, thereby exerting antiapoptotic effects and contributing to EAC cell survival; miR-196a may also constitute a good biomarker of progression during BE-EAC carcinogenesis; and thirdly, The miR-106b-25 polycistron is activated by genomic amplification and is involved in esophageal neoplastic progression and proliferation via the suppression of two target genes, p21 and Bim.
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U2 - 10.1016/j.coph.2009.08.009
DO - 10.1016/j.coph.2009.08.009
M3 - Review article
C2 - 19773200
AN - SCOPUS:70449500921
SN - 1471-4892
VL - 9
SP - 727
EP - 732
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
IS - 6
ER -