MicroRNAs: Expression, avoidance and subversion by vertebrate viruses

Peter Sarnow, Catherine L. Jopling, Kara L. Norman, Sylvia Schütz, Karen A. Wehner

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


MicroRNAs (miRNAs), which can be expressed in a cell-type and tissue-specific manner, can influence the activities of genes that control cell growth and differentiation. Viruses often have clear tissue tropisms, raising the possibility that cellular miRNAs might modulate their pathogenesis. In this Review, we discuss recent findings that some vertebrate viruses either encode miRNAs or subvert cellular miRNAs, and that these miRNAs participate in both the infectious and the latent phase of the viral life cycle.

Original languageEnglish (US)
Pages (from-to)651-659
Number of pages9
JournalNature Reviews Microbiology
Issue number9
StatePublished - Sep 2006
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • General Immunology and Microbiology
  • Infectious Diseases


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