microRNAs: A Safeguard against Turmoil?

Anthony K.L. Leung; Phillip A. Sharp

doi:10.1016/j.cell.2007.08.010

microRNAs: A Safeguard against Turmoil?

Anthony K.L. Leung, Phillip A. Sharp

Research output: Contribution to journal › Short survey › peer-review

167 Scopus citations

Abstract

Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress.

Original language	English (US)
Pages (from-to)	581-585
Number of pages	5
Journal	Cell
Volume	130
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2007.08.010
State	Published - Aug 24 2007
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2007.08.010

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@article{e6f8bf00a8244d33b85d9eb11b86519e,

title = "microRNAs: A Safeguard against Turmoil?",

abstract = "Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress.",

author = "Leung, {Anthony K.L.} and Sharp, {Phillip A.}",

note = "Funding Information: We thank M. Ebert, L. Aleman, J. Neilson, G. Doran, C. Nielsen, M. Howarth, and N. Kedersha for critical comments on the manuscript and M. Lindstrom for the illustration. This work is supported by the NSF, an NCI Program Project Grant (PAS), and an NCI Cancer Center Support (Core) Grant. AKLL is a Leukemia and Lymphoma Society Special Fellow.",

year = "2007",

month = aug,

day = "24",

doi = "10.1016/j.cell.2007.08.010",

language = "English (US)",

volume = "130",

pages = "581--585",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - microRNAs

T2 - A Safeguard against Turmoil?

AU - Leung, Anthony K.L.

AU - Sharp, Phillip A.

N1 - Funding Information: We thank M. Ebert, L. Aleman, J. Neilson, G. Doran, C. Nielsen, M. Howarth, and N. Kedersha for critical comments on the manuscript and M. Lindstrom for the illustration. This work is supported by the NSF, an NCI Program Project Grant (PAS), and an NCI Cancer Center Support (Core) Grant. AKLL is a Leukemia and Lymphoma Society Special Fellow.

PY - 2007/8/24

Y1 - 2007/8/24

N2 - Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress.

AB - Emerging data suggest that microRNAs (miRNAs) are instrumental in a variety of stress responses in addition to their more recognized role in development. Surprisingly, miRNAs, which normally suppress expression of target transcripts, may become activators of expression during stress. This might be partially explained by new interactions of miRNA/Argonaute complexes with RNA-binding proteins that relocate from different subcellular compartments during stress.

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UR - http://www.scopus.com/inward/citedby.url?scp=34547938506&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2007.08.010

DO - 10.1016/j.cell.2007.08.010

M3 - Short survey

C2 - 17719533

AN - SCOPUS:34547938506

SN - 0092-8674

VL - 130

SP - 581

EP - 585

JO - Cell

JF - Cell

IS - 4

ER -

microRNAs: A Safeguard against Turmoil?

Abstract

ASJC Scopus subject areas

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