TY - JOUR
T1 - Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage
AU - Zhang, Zhen
AU - Zhang, Ze
AU - Lu, Hong
AU - Yang, Qingwu
AU - Wu, He
AU - Wang, Jian
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China 81200885, Heilongjiang Postdoctoral Science-Research Foundation LBH-Q13120, the Natural Science Foundation of Heilongjiang Province of China LC2013C30, the Foundation of the First Clinical Hospital of Harbin Medical University 2012LX004, an American Heart Association grant 13GRNT15730001, and the National Institutes of Health (R01NS078026, R01AT007317). We thank Claire Levine for assistance with this manuscript.
Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediators, such as Toll-like receptor 4, matrix metalloproteinases, high-mobility group protein box-1, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron, in secondary injury after ICH and highlights the potential targets for ICH treatment.
AB - Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediators, such as Toll-like receptor 4, matrix metalloproteinases, high-mobility group protein box-1, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron, in secondary injury after ICH and highlights the potential targets for ICH treatment.
KW - Inflammatory mediators
KW - Intracerebral hemorrhage
KW - Microglia
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U2 - 10.1007/s12035-016-9785-6
DO - 10.1007/s12035-016-9785-6
M3 - Review article
C2 - 26894396
AN - SCOPUS:84958739618
SN - 0893-7648
VL - 54
SP - 1874
EP - 1886
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 3
ER -