Microglial Polarization and Inflammatory Mediators After Intracerebral Hemorrhage

Zhen Zhang, Ze Zhang, Hong Lu, Qingwu Yang, He Wu, Jian Wang

Research output: Contribution to journalReview articlepeer-review

97 Scopus citations


Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and morbidity. When a diseased artery within the brain bursts, expansion and absorption of the resulting hematoma trigger a series of reactions that cause primary and secondary brain injury. Microglia are extremely important for removing the hematoma and clearing debris, but they are also a source of ongoing inflammation. This article discusses the role of microglial activation/polarization and related inflammatory mediators, such as Toll-like receptor 4, matrix metalloproteinases, high-mobility group protein box-1, nuclear factor erythroid 2-related factor 2, heme oxygenase, and iron, in secondary injury after ICH and highlights the potential targets for ICH treatment.

Original languageEnglish (US)
Pages (from-to)1874-1886
Number of pages13
JournalMolecular Neurobiology
Issue number3
StatePublished - Apr 1 2017


  • Inflammatory mediators
  • Intracerebral hemorrhage
  • Microglia

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience


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