Microcomputed tomography with a second generation photon-counting x-ray detector - Contrast analysis and material separation

X. Wang, D. Meier, P. Oya, G. E. Maehlum, D. J. Wagenaar, B. M.W. Tsui, B. E. Patt, E. C. Frey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Scopus citations


The overall aim of this work was to evaluate the potential for improving in vivo small animal microCT through the use of an energy resolved photon-counting detector. To this end, we developed and evaluated a prototype microCT system based on a second-generation photon-counting x-ray detector which simultaneously counted photons with energies above six energy thresholds. First, we developed a threshold tuning procedure to reduce the dependence of detector uniformity and to reduce ring artifacts. Next, we evaluated the system in terms of the contrast-to-noise ratio in different energy windows for different target materials. These differences provided the possibility to weight the data acquired in different windows in order to optimize the contrast-to-noise ratio. We also explored the ability of the system to use data from different energy windows to aid in distinguishing various materials. We found that the energy discrimination capability provided the possibility for improved contrast-to-noise ratios and allowed separation of more than two materials, e.g., bone, soft-tissue and one or more contrast materials having K-absorption edges in the energy ranges of interest.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2010
Subtitle of host publicationPhysics of Medical Imaging
EditionPART 1
StatePublished - 2010
Externally publishedYes
EventMedical Imaging 2010: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 15 2010Feb 18 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
NumberPART 1
ISSN (Print)1605-7422


OtherMedical Imaging 2010: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • Contrast analysis
  • Energy resolved photon-counting
  • Material separation
  • Ring reduction

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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