Microcarriers in the engineering of cartilage and bone

Jos Malda, Carmelita G. Frondoza

Research output: Contribution to journalReview articlepeer-review

179 Scopus citations


A major problem in tissue engineering is the availability of a sufficient number of cells with the appropriate phenotype for delivery to damaged or diseased cartilage and bone; the challenge is to amplify cell numbers and maintain the appropriate phenotype for tissue repair and restoration of function. The microcarrier bioreactor culture system offers an attractive method for cell amplification and enhancement of phenotype expression. Besides serving as substrates for the propagation of anchorage-dependent cells, microcarriers can also be used to deliver the expanded undifferentiated or differentiated cells to the site of the defect. The present article provides an overview of the microcarrier culture system, its utility as an in vitro research tool and its potential applications in tissue engineering, particularly in the repair of cartilage and bone. Crown

Original languageEnglish (US)
Pages (from-to)299-304
Number of pages6
JournalTrends in Biotechnology
Issue number7
StatePublished - Jul 1 2006

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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