Microbial transformation of ginsenoside Rb1 by Rhizopus stolonifer and Curvularia lunata

Aling Dong, Min Ye, Hongzhu Guo, Junhua Zheng, Dean Guo

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Of 49 microbial strains screened for their capabilities to transform ginsenoside Rb1, Rhizopus stolonifer and Curvularia lunata produced four key metabolites: 3-O-[β-D-glucopyranosyl-(1,2)-β-D-glucopyranosyl]-20-O- [β-D-glucopyranosyl]-3β, 12β, 20(S)-trihydroxydammar-24-ene (1), 3-O-[β-D-glucopyranosyl-(1,2)-β-D-glucopyranosyl]-20-O- [β-D-glucopyranosyl]-3β,12β, 20(S)-trihydroxydammar-24-ol (2), 3-O-[β-D-glucopyranosyl-(1,2)-β-D-glucopyranosyl]-3β, 12β, 20(S)-trihydroxydammar-24-ene (3), and 3-O-β-D-glucopyranosyl-3β, 12β, 20(S)-trihydroxydammar-24-ene (4), identified by TOF-MS, 1H- and 13C-NMR spectral data. Metabolites 1, 3 and 4 were from the incubation with R. stolonifer, and 1 and 2 from the incubation with C. lunata. Compound 2 was identified as a new compound.

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalBiotechnology Letters
Issue number4
StatePublished - Feb 2003
Externally publishedYes


  • Biotransformation
  • Curvularia lunata
  • Ginsenoside
  • Rhizopus stolonifer

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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