Micro sized implantable ball lens-based fiber optic probe design

Jaepyeong Cha, Jin U. Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A micro sized implantable ball lens-based fiber optic probe design is described for continuous monitoring of brain activity in freely behaving mice. A prototype uses a 500-micron ball lens and a highly flexible 350-micron-diameter fiber bundle, which are enclosed by a 21G stainless steel sheath. Several types and thickness of brain tissue, consisting of fluorescent probes such as GFP, GCaMP3 calcium indicator, are used to evaluate the performance of the imaging probe. Measured working distance is approximately 400-μm, but is long enough to detect neural activities from cortical and cerebellar tissues of mice brain.

Original languageEnglish (US)
Title of host publicationOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV
PublisherSPIE
ISBN (Print)9780819498519
DOIs
StatePublished - 2014
Externally publishedYes
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV - San Francisco, CA, United States
Duration: Feb 1 2014Feb 2 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8938
ISSN (Print)1605-7422

Other

OtherOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIV
Country/TerritoryUnited States
CitySan Francisco, CA
Period2/1/142/2/14

Keywords

  • Brain activity detection
  • Fiber-optic sensing
  • Fluorescence imaging
  • Implantable devices
  • Micro ball lens

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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