Micro fluidic device fabrication by thermoplastic hot-embossing

Shuang Yang, Don L. DeVoe

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Scopus citations


Due to their low cost compatibility with replication-based fabrication methods, thermoplastics represent an exceptionally attractive family of materials for the fabrication of lab-on-A-chip platforms. A diverse range of thermoplastic materials suitable for micro fluidic fabrication is available, offering a wide selection of mechanical and chemical properties that can be leveraged and further tailored for speci fi c applications. While highthroughput embossing methods such as reel-To-reel processing of thermoplastics is an attractive method for industrial micro fluidic chip production, the use of single chip hot embossing is a cost-effective technique for realizing high-quality micro fluidic devices during the prototyping stage. Here we describe methods for the replication of microscale features in two thermoplastics, polymethylmethacrylate (PMMA) and polycarbonate (PC), using hot embossing from a silicon template fabricated by deep reactive-ion etching.

Original languageEnglish (US)
Title of host publicationMicrofluidic Diagnostics
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Number of pages9
ISBN (Print)9781627031332
StatePublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Hot embossing
  • Imprinting
  • Polycarbonate
  • Polymethylmethacrylate
  • Replication
  • Thermoplastics

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


Dive into the research topics of 'Micro fluidic device fabrication by thermoplastic hot-embossing'. Together they form a unique fingerprint.

Cite this