Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

R. L. Schnaar; A. Yamamoto; K. Furukawa; S. Yamashiro; M. Shin; M. Okada; S. Fukumoto; M. Haraguchi; N. Takeda; K. Fujimura; M. Sakae; M. Kishikawa; H. Shiku; K. Furukawa; S. Aizawa

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

R. L. Schnaar, A. Yamamoto, K. Furukawa, S. Yamashiro, M. Shin, M. Okada, S. Fukumoto, M. Haraguchi, N. Takeda, K. Fujimura, M. Sakae, M. Kishikawa, H. Shiku, K. Furukawa, S. Aizawa

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Mice genetically engineered to lack complex brain gangliosides developed normal brain anatomy, histology, and ultrastructure, although they demonstrated a modest change in central nervous system conduction velocity.

Original language	English (US)
Pages (from-to)	195-200
Number of pages	6
Journal	Chemtracts
Volume	11
Issue number	3
State	Published - Mar 1998

ASJC Scopus subject areas

General Chemistry
Biochemistry
Molecular Biology

Cite this

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title = "Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system",

abstract = "Mice genetically engineered to lack complex brain gangliosides developed normal brain anatomy, histology, and ultrastructure, although they demonstrated a modest change in central nervous system conduction velocity.",

author = "Schnaar, {R. L.} and A. Yamamoto and K. Furukawa and S. Yamashiro and M. Shin and M. Okada and S. Fukumoto and M. Haraguchi and N. Takeda and K. Fujimura and M. Sakae and M. Kishikawa and H. Shiku and K. Furukawa and S. Aizawa",

year = "1998",

month = mar,

language = "English (US)",

volume = "11",

pages = "195--200",

journal = "Chemtracts",

issn = "1431-9268",

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TY - JOUR

T1 - Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

AU - Schnaar, R. L.

AU - Yamamoto, A.

AU - Furukawa, K.

AU - Yamashiro, S.

AU - Shin, M.

AU - Okada, M.

AU - Fukumoto, S.

AU - Haraguchi, M.

AU - Takeda, N.

AU - Fujimura, K.

AU - Sakae, M.

AU - Kishikawa, M.

AU - Shiku, H.

AU - Furukawa, K.

AU - Aizawa, S.

PY - 1998/3

Y1 - 1998/3

N2 - Mice genetically engineered to lack complex brain gangliosides developed normal brain anatomy, histology, and ultrastructure, although they demonstrated a modest change in central nervous system conduction velocity.

AB - Mice genetically engineered to lack complex brain gangliosides developed normal brain anatomy, histology, and ultrastructure, although they demonstrated a modest change in central nervous system conduction velocity.

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UR - http://www.scopus.com/inward/citedby.url?scp=0031768116&partnerID=8YFLogxK

M3 - Review article

AN - SCOPUS:0031768116

SN - 1431-9268

VL - 11

SP - 195

EP - 200

JO - Chemtracts

JF - Chemtracts

IS - 3

ER -

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

Abstract

ASJC Scopus subject areas

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