Abstract
Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury, and disease.
Original language | English (US) |
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Journal | eLife |
Volume | 12 |
DOIs | |
State | Published - Apr 14 2023 |
Keywords
- immunology
- inflammation
- major histocompatibility complex
- mouse
- multiple sclerosis
- neuroscience
- oligodendrocytes
ASJC Scopus subject areas
- General Neuroscience
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology