MHC class I and MHC class II reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Em P. Harrington, Riley B. Catenacci, Matthew D. Smith, Dongeun Heo, Cecilia E. Miller, Keya R. Meyers, Jenna Glatzer, Dwight E. Bergles, Peter A. Calabresi

Research output: Contribution to journalArticlepeer-review

Abstract

Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury, and disease.

Original languageEnglish (US)
JournaleLife
Volume12
DOIs
StatePublished - Apr 14 2023

Keywords

  • immunology
  • inflammation
  • major histocompatibility complex
  • mouse
  • multiple sclerosis
  • neuroscience
  • oligodendrocytes

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

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