MHC class i and MHC class ii reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Em P. Harrington; Riley B. Catenacci; Matthew D. Smith; Dongeun Heo; Cecilia E. Miller; Keya R. Meyers; Jenna Glatzer; Dwight E. Bergles; Peter A. Calabresi

doi:10.7554/eLife.82938

MHC class i and MHC class ii reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Em P. Harrington, Riley B. Catenacci, Matthew D. Smith, Dongeun Heo, Cecilia E. Miller, Keya R. Meyers, Jenna Glatzer, Dwight E. Bergles, Peter A. Calabresi

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury and disease.

Original language	English (US)
Article number	e82938
Journal	eLife
Volume	12
DOIs	https://doi.org/10.7554/eLife.82938
State	Published - Apr 2023

ASJC Scopus subject areas

General Immunology and Microbiology
General Biochemistry, Genetics and Molecular Biology
General Neuroscience

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10.7554/eLife.82938

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abstract = "Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury and disease.",

author = "Harrington, {Em P.} and Catenacci, {Riley B.} and Smith, {Matthew D.} and Dongeun Heo and Miller, {Cecilia E.} and Meyers, {Keya R.} and Jenna Glatzer and Bergles, {Dwight E.} and Calabresi, {Peter A.}",

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AU - Harrington, Em P.

AU - Catenacci, Riley B.

AU - Smith, Matthew D.

AU - Heo, Dongeun

AU - Miller, Cecilia E.

AU - Meyers, Keya R.

AU - Glatzer, Jenna

AU - Bergles, Dwight E.

AU - Calabresi, Peter A.

PY - 2023/4

Y1 - 2023/4

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AB - Oligodendrocytes and their progenitors upregulate MHC pathways in response to inflammation, but the frequency of this phenotypic change is unknown and the features of these immune oligodendroglia are poorly defined. We generated MHC class I and II transgenic reporter mice to define their dynamics in response to inflammatory demyelination, providing a means to monitor MHC activation in diverse cell types in living mice and define their roles in aging, injury and disease.

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MHC class i and MHC class ii reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Abstract

ASJC Scopus subject areas

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