TY - JOUR
T1 - Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines
AU - Banerjee, Shailesh P.
AU - Snyder, Solomon H.
PY - 1973
Y1 - 1973
N2 - A variety of mammalian and avion tissues N- and Q-methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S-adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.
AB - A variety of mammalian and avion tissues N- and Q-methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S-adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.
UR - http://www.scopus.com/inward/record.url?scp=0015820523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0015820523&partnerID=8YFLogxK
U2 - 10.1126/science.182.4107.74
DO - 10.1126/science.182.4107.74
M3 - Article
C2 - 4581052
AN - SCOPUS:0015820523
SN - 0036-8075
VL - 182
SP - 74
EP - 75
JO - Science
JF - Science
IS - 4107
ER -