Methyltetrahydrofolic acid mediates N- and O-methylation of biogenic amines

Shailesh P. Banerjee, Solomon H. Snyder

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


A variety of mammalian and avion tissues N- and Q-methylate indoleamines and phenylethylamines, with methyltetrahydrofolic acid as the methyl donor. Because it is considerably more efficient than S-adenosylmethionine, methyltetrahydrofolic acid may be the natural methyl donor in this reaction. With methyltetrahydrofolic acid, serotonin is O-methylated to 5-methoxytryptamine, a novel indoleamine in mammalian brain.

Original languageEnglish (US)
Pages (from-to)74-75
Number of pages2
Issue number4107
StatePublished - 1973

ASJC Scopus subject areas

  • General


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